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Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis
BACKGROUND: The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are u...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441293/ https://www.ncbi.nlm.nih.gov/pubmed/25961664 http://dx.doi.org/10.12659/MSM.893553 |
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author | Yang, Xiang-wu Li, Peng-zhou Zhu, Li-yong Zhu, Shai-hong |
author_facet | Yang, Xiang-wu Li, Peng-zhou Zhu, Li-yong Zhu, Shai-hong |
author_sort | Yang, Xiang-wu |
collection | PubMed |
description | BACKGROUND: The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain. MATERIAL/METHODS: We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% confidence interval (CI) were pooled. RESULTS: Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27–0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger’s or Begg’s tests. CONCLUSIONS: Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies. |
format | Online Article Text |
id | pubmed-4441293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44412932015-06-01 Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis Yang, Xiang-wu Li, Peng-zhou Zhu, Li-yong Zhu, Shai-hong Med Sci Monit Meta-Analysis BACKGROUND: The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain. MATERIAL/METHODS: We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% confidence interval (CI) were pooled. RESULTS: Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27–0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger’s or Begg’s tests. CONCLUSIONS: Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies. International Scientific Literature, Inc. 2015-05-11 /pmc/articles/PMC4441293/ /pubmed/25961664 http://dx.doi.org/10.12659/MSM.893553 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Meta-Analysis Yang, Xiang-wu Li, Peng-zhou Zhu, Li-yong Zhu, Shai-hong Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title | Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title_full | Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title_fullStr | Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title_full_unstemmed | Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title_short | Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis |
title_sort | effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441293/ https://www.ncbi.nlm.nih.gov/pubmed/25961664 http://dx.doi.org/10.12659/MSM.893553 |
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