Cargando…

The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met(+) Hepatocellular Carcinoma

BACKGROUND: c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine ki...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steinway, Steven N., Dang, Hien, You, Hanning, Rountree, C. Bart, Ding, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441360/ https://www.ncbi.nlm.nih.gov/pubmed/26000702 http://dx.doi.org/10.1371/journal.pone.0128159

Ejemplares similares

Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma
por: Dang, Hien, et al.
Publicado: (2015)

Proliferation of Colorectal Cancer Is Promoted by Two Signaling Transduction Expression Patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK
por: Yao, Yong-Liang, et al.
Publicado: (2013)

Reconstitution of Mammary Gland Development In Vitro: Requirement of c-met and c-erbB2 Signaling for Branching and Alveolar Morphogenesis
por: Niemann, Catherin, et al.
Publicado: (1998)

Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties
por: Castoldi, R., et al.
Publicado: (2012)

Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB.
por: Aasland, R., et al.
Publicado: (1988)

Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer
por: Gautam, Shailendra K., et al.
Publicado: (2020)

HGF-independent Potentiation of EGFR Action by c-Met
por: Dulak, Austin M., et al.
Publicado: (2011)

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling
por: Booth, Laurence, et al.
Publicado: (2016)

Targeting the HGF-cMET Axis in Hepatocellular Carcinoma
por: Venepalli, Neeta K., et al.
Publicado: (2013)

Clinical Development of c-MET Inhibition in Hepatocellular Carcinoma
por: Lee, Joycelyn J. X., et al.
Publicado: (2015)

The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma
por: Wang, Haiyu, et al.
Publicado: (2020)

Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome
por: Leung, Kin K., et al.
Publicado: (2014)

c-Met inhibitors
por: Mughal, Anum, et al.
Publicado: (2013)

MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition
por: Ortiz-Zapater, Elena, et al.
Publicado: (2017)

An autophagy-inducing stapled peptide promotes c-MET degradation and overrides adaptive resistance to sorafenib in c-MET(+) hepatocellular carcinoma
por: Gao, Shan, et al.
Publicado: (2022)

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells
por: Presutti, Dario, et al.
Publicado: (2015)

C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis.
por: Parkes, H. C., et al.
Publicado: (1990)

Regulation of the EGFR/ErbB signalling by clathrin in response to various ligands in hepatocellular carcinoma cell lines
por: Liu, Yuanhui, et al.
Publicado: (2020)

Expression of HER2/c-erbB-2, EGFR Protein in Gastric Carcinoma and its Clinical Significance
por: Cheng, Guoxiong, et al.
Publicado: (2019)

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma
por: Ma, Xiao-Lu, et al.
Publicado: (2023)

c-erbB-3 protein expression in ovarian tumours.
por: Simpson, B. J., et al.
Publicado: (1995)

Expression of MIF and c-erbB-2 in endometrial cancer
por: XIAO, WEI, et al.
Publicado: (2016)

Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3
por: Young, Christian D, et al.
Publicado: (2008)

Modulation of ErbB2 Blockade in ErbB2-Positive Cancers: The Role of ErbB2 Mutations and PHLDA1
por: Li, Guangyuan, et al.
Publicado: (2014)

Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes
por: Kelley, Mary B., et al.
Publicado: (2022)

Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs
por: Lin, Tingting, et al.
Publicado: (2019)

Critical Role of MetR/MetB/MetC/MetX in Cysteine and Methionine Metabolism, Fungal Development, and Virulence of Alternaria alternata
por: Gai, Yunpeng, et al.
Publicado: (2021)

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
por: Park, Chi Hoon, et al.
Publicado: (2016)

Prognostic role of ERBB2, MET and VEGFA expression in metastatic colorectal cancer patients treated with anti-EGFR antibodies
por: Takahashi, Naoki, et al.
Publicado: (2016)

SUN-442 EGFR/ErbB2 Targeted Therapy for Aggressive Prolactinomas
por: Cooper, Odelia, et al.
Publicado: (2019)

Epigenetic Upregulation of HGF and c-Met Drives Metastasis in Hepatocellular Carcinoma
por: Ogunwobi, Olorunseun O., et al.
Publicado: (2013)

Recent developments of c‐Met as a therapeutic target in hepatocellular carcinoma
por: Bouattour, Mohamed, et al.
Publicado: (2018)

The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future
por: Woo, Hyun Young, et al.
Publicado: (2020)

c-erbB-2 expression in benign and malignant breast disease.
por: Gusterson, B. A., et al.
Publicado: (1988)

Pattern of expression of c-erbB-2 oncoprotein in human fetuses.
por: Quirke, P., et al.
Publicado: (1989)

c-erbB-4 protein expression in human breast cancer
por: Kew, T Y, et al.
Publicado: (2000)

Expression of c-erbB-2 protein product in bladder cancer.
por: Wright, C., et al.
Publicado: (1990)

Expression of c-erbB-2 protein in papillary thyroid carcinomas.
por: Haugen, D. R., et al.
Publicado: (1992)

Expression of c-erbB3 protein in primary breast carcinomas.
por: Naidu, R., et al.
Publicado: (1998)

c-erbB-2 protein expression in astrocytic tumors of the brain
por: Reszeć, Joanna, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_nfmmd3hc9oid03e46dasisb23u