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Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population

BACKGROUND: Despite observational evidence from epidemiological and clinical studies associating sex hormones with various cardiometabolic risk factors or diseases, pathophysiological explanations are sparse to date. To reveal putative functional insights, we analyzed associations between sex hormon...

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Autores principales: Haring, Robin, Schurmann, Claudia, Homuth, Georg, Steil, Leif, Völker, Uwe, Völzke, Henry, Keevil, Brian G., Nauck, Matthias, Wallaschofski, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441431/
https://www.ncbi.nlm.nih.gov/pubmed/26001193
http://dx.doi.org/10.1371/journal.pone.0127466
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author Haring, Robin
Schurmann, Claudia
Homuth, Georg
Steil, Leif
Völker, Uwe
Völzke, Henry
Keevil, Brian G.
Nauck, Matthias
Wallaschofski, Henri
author_facet Haring, Robin
Schurmann, Claudia
Homuth, Georg
Steil, Leif
Völker, Uwe
Völzke, Henry
Keevil, Brian G.
Nauck, Matthias
Wallaschofski, Henri
author_sort Haring, Robin
collection PubMed
description BACKGROUND: Despite observational evidence from epidemiological and clinical studies associating sex hormones with various cardiometabolic risk factors or diseases, pathophysiological explanations are sparse to date. To reveal putative functional insights, we analyzed associations between sex hormone levels and whole blood gene expression profiles. METHODS: We used data of 991 individuals from the population-based Study of Health in Pomerania (SHIP-TREND) with whole blood gene expression levels determined by array-based transcriptional profiling and serum concentrations of total testosterone (TT), sex hormone-binding globulin (SHBG), free testosterone (free T), dehydroepiandrosterone sulfate (DHEAS), androstenedione (AD), estradiol (E2), and estrone (E1) measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay. Associations between sex hormone concentrations and gene expression profiles were analyzed using sex-specific regression models adjusted for age, body mass index, and technical covariables. RESULTS: In men, positive correlations were detected between AD and DDIT4 mRNA levels, as well as between SHBG and the mRNA levels of RPIA, RIOK3, GYPB, BPGM, and RAB2B. No additional significant associations were observed. CONCLUSIONS: Besides the associations between AD and DDIT4 expression and SHBG and the transcript levels of RPIA, RIOK3, GYPB, BPGM, and RAB2B, the present study did not indicate any association between sex hormone concentrations and whole blood gene expression profiles in men and women from the general population.
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spelling pubmed-44414312015-05-28 Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population Haring, Robin Schurmann, Claudia Homuth, Georg Steil, Leif Völker, Uwe Völzke, Henry Keevil, Brian G. Nauck, Matthias Wallaschofski, Henri PLoS One Research Article BACKGROUND: Despite observational evidence from epidemiological and clinical studies associating sex hormones with various cardiometabolic risk factors or diseases, pathophysiological explanations are sparse to date. To reveal putative functional insights, we analyzed associations between sex hormone levels and whole blood gene expression profiles. METHODS: We used data of 991 individuals from the population-based Study of Health in Pomerania (SHIP-TREND) with whole blood gene expression levels determined by array-based transcriptional profiling and serum concentrations of total testosterone (TT), sex hormone-binding globulin (SHBG), free testosterone (free T), dehydroepiandrosterone sulfate (DHEAS), androstenedione (AD), estradiol (E2), and estrone (E1) measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay. Associations between sex hormone concentrations and gene expression profiles were analyzed using sex-specific regression models adjusted for age, body mass index, and technical covariables. RESULTS: In men, positive correlations were detected between AD and DDIT4 mRNA levels, as well as between SHBG and the mRNA levels of RPIA, RIOK3, GYPB, BPGM, and RAB2B. No additional significant associations were observed. CONCLUSIONS: Besides the associations between AD and DDIT4 expression and SHBG and the transcript levels of RPIA, RIOK3, GYPB, BPGM, and RAB2B, the present study did not indicate any association between sex hormone concentrations and whole blood gene expression profiles in men and women from the general population. Public Library of Science 2015-05-22 /pmc/articles/PMC4441431/ /pubmed/26001193 http://dx.doi.org/10.1371/journal.pone.0127466 Text en © 2015 Haring et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Haring, Robin
Schurmann, Claudia
Homuth, Georg
Steil, Leif
Völker, Uwe
Völzke, Henry
Keevil, Brian G.
Nauck, Matthias
Wallaschofski, Henri
Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title_full Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title_fullStr Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title_full_unstemmed Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title_short Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population
title_sort associations between serum sex hormone concentrations and whole blood gene expression profiles in the general population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441431/
https://www.ncbi.nlm.nih.gov/pubmed/26001193
http://dx.doi.org/10.1371/journal.pone.0127466
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