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Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status
BACKGROUND: Ribonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit. Expression levels of each subunit have been implicated in prognos...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441434/ https://www.ncbi.nlm.nih.gov/pubmed/26001082 http://dx.doi.org/10.1371/journal.pone.0127600 |
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author | Mah, Vei Alavi, Mohammad Márquez-Garbán, Diana C. Maresh, Erin L. Kim, Sara R. Horvath, Steve Bagryanova, Lora Huerta-Yepez, Sara Chia, David Pietras, Richard Goodglick, Lee |
author_facet | Mah, Vei Alavi, Mohammad Márquez-Garbán, Diana C. Maresh, Erin L. Kim, Sara R. Horvath, Steve Bagryanova, Lora Huerta-Yepez, Sara Chia, David Pietras, Richard Goodglick, Lee |
author_sort | Mah, Vei |
collection | PubMed |
description | BACKGROUND: Ribonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit. Expression levels of each subunit have been implicated in prognostic outcomes in several different types of cancers. EXPERIMENTAL DESIGN: Immunohistochemistry for RRM1 and RRM2 was performed on a lung cancer tissue microarray (TMA) and analyzed. 326 patients from the microarray were included in this study. RESULTS: In non-small cell lung cancer (NSCLC), RRM2 expression was strongly predictive of disease-specific survival in women, non-smokers and former smokers who had quit at least 10 years prior to being diagnosed with lung cancer. Higher expression was associated with worse survival. This was not the case for men, current smokers and those who had stopped smoking for shorter periods of time. RRM1 was not predictive of survival outcomes in any subset of the patient group. CONCLUSION: RRM2, but not RRM1, is a useful predictor of survival outcome in certain subsets of NSCLC patients. |
format | Online Article Text |
id | pubmed-4441434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44414342015-05-28 Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status Mah, Vei Alavi, Mohammad Márquez-Garbán, Diana C. Maresh, Erin L. Kim, Sara R. Horvath, Steve Bagryanova, Lora Huerta-Yepez, Sara Chia, David Pietras, Richard Goodglick, Lee PLoS One Research Article BACKGROUND: Ribonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit. Expression levels of each subunit have been implicated in prognostic outcomes in several different types of cancers. EXPERIMENTAL DESIGN: Immunohistochemistry for RRM1 and RRM2 was performed on a lung cancer tissue microarray (TMA) and analyzed. 326 patients from the microarray were included in this study. RESULTS: In non-small cell lung cancer (NSCLC), RRM2 expression was strongly predictive of disease-specific survival in women, non-smokers and former smokers who had quit at least 10 years prior to being diagnosed with lung cancer. Higher expression was associated with worse survival. This was not the case for men, current smokers and those who had stopped smoking for shorter periods of time. RRM1 was not predictive of survival outcomes in any subset of the patient group. CONCLUSION: RRM2, but not RRM1, is a useful predictor of survival outcome in certain subsets of NSCLC patients. Public Library of Science 2015-05-22 /pmc/articles/PMC4441434/ /pubmed/26001082 http://dx.doi.org/10.1371/journal.pone.0127600 Text en © 2015 Mah et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Mah, Vei Alavi, Mohammad Márquez-Garbán, Diana C. Maresh, Erin L. Kim, Sara R. Horvath, Steve Bagryanova, Lora Huerta-Yepez, Sara Chia, David Pietras, Richard Goodglick, Lee Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title | Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title_full | Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title_fullStr | Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title_full_unstemmed | Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title_short | Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status |
title_sort | ribonucleotide reductase subunit m2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441434/ https://www.ncbi.nlm.nih.gov/pubmed/26001082 http://dx.doi.org/10.1371/journal.pone.0127600 |
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