Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)(1) or hyperactivation above maximum (e.g. self-reactive BCR)(2–3) thresholds of signaling strength causes negative selection. In ~25% of cases, acute lympho...

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Detalles Bibliográficos
Autores principales: Chen, Zhengshan, Shojaee, Seyedmehdi, Buchner, Maike, Geng, Huimin, Lee, Jae Woong, Klemm, Lars, Titz, Björn, Graeber, Thomas G., Park, Eugene, Tan, Ying Xim, Satterthwaite, Anne, Paietta, Elisabeth, Hunger, Stephen P., Willman, Cheryl L., Melnick, Ari, Loh, Mignon L., Jung, Jae U., Coligan, John E., Bolland, Silvia, Mak, Tak W., Limnander, Andre, Jumaa, Hassan, Reth, Michael, Weiss, Arthur, Lowell, Clifford A., Müschen, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441554/
https://www.ncbi.nlm.nih.gov/pubmed/25799995
http://dx.doi.org/10.1038/nature14231

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