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Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model

BACKGROUND: Synthetic hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and their composite are promising biomaterials, specifically in the orthopedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft...

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Autores principales: Bigham-Sadegh, Amin, Karimi, Iraj, Shadkhast, Mohamad, Mahdavi, Mohamad-Hosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441635/
https://www.ncbi.nlm.nih.gov/pubmed/25308902
http://dx.doi.org/10.1007/s10195-014-0323-x
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author Bigham-Sadegh, Amin
Karimi, Iraj
Shadkhast, Mohamad
Mahdavi, Mohamad-Hosein
author_facet Bigham-Sadegh, Amin
Karimi, Iraj
Shadkhast, Mohamad
Mahdavi, Mohamad-Hosein
author_sort Bigham-Sadegh, Amin
collection PubMed
description BACKGROUND: Synthetic hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and their composite are promising biomaterials, specifically in the orthopedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft substitutes are gradually gaining increased acceptability. To stimulate the process of bone healing, several methods have been used previously, including ultrasound, electrical stimulation, exposure to electromagnetic fields, bone grafts, interporous hydroxyapatite (as a bone graft substitute) and bone growth factors. The following study was designed to evaluate the effects of the concurrent usage of hydroxyapatite with demineralized calf fetal growth plate (DCFGP) on the bone healing process. MATERIALS AND METHODS: Fifteen female New Zealand white rabbits were used in this study. A mid-radius bone defect was created and in the first group (n = 5) was filled with hydroxyapatite, in the second group (n = 5) with hydroxyapatite and DCFGP, and finally in the third group (n = 5) with DCFGP alone. Radiological and histopathological evaluations were performed blindly and the results scored and analyzed statistically. RESULTS: There was a significant difference for bone formation and remodeling at the 8th post-operative week radiographic assessment (P< 0.05), when the hydroxyapatite–DCFGP group was superior to other groups. On the contrary, macroscopical and histopathological evaluation did not revealed significant differences between the three groups CONCLUSION: Given the contrasting results of the radiographic assessment and the macro-/microscopic analysis of the healing response, further studies are needed before considering DCFGP-HA as a feasible alternative to HA alone, especially considering the potential hazards and costs of animal-derived biomaterials. LEVEL OF EVIDENCE: Not applicable.
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spelling pubmed-44416352015-05-28 Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model Bigham-Sadegh, Amin Karimi, Iraj Shadkhast, Mohamad Mahdavi, Mohamad-Hosein J Orthop Traumatol Original Article BACKGROUND: Synthetic hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and their composite are promising biomaterials, specifically in the orthopedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft substitutes are gradually gaining increased acceptability. To stimulate the process of bone healing, several methods have been used previously, including ultrasound, electrical stimulation, exposure to electromagnetic fields, bone grafts, interporous hydroxyapatite (as a bone graft substitute) and bone growth factors. The following study was designed to evaluate the effects of the concurrent usage of hydroxyapatite with demineralized calf fetal growth plate (DCFGP) on the bone healing process. MATERIALS AND METHODS: Fifteen female New Zealand white rabbits were used in this study. A mid-radius bone defect was created and in the first group (n = 5) was filled with hydroxyapatite, in the second group (n = 5) with hydroxyapatite and DCFGP, and finally in the third group (n = 5) with DCFGP alone. Radiological and histopathological evaluations were performed blindly and the results scored and analyzed statistically. RESULTS: There was a significant difference for bone formation and remodeling at the 8th post-operative week radiographic assessment (P< 0.05), when the hydroxyapatite–DCFGP group was superior to other groups. On the contrary, macroscopical and histopathological evaluation did not revealed significant differences between the three groups CONCLUSION: Given the contrasting results of the radiographic assessment and the macro-/microscopic analysis of the healing response, further studies are needed before considering DCFGP-HA as a feasible alternative to HA alone, especially considering the potential hazards and costs of animal-derived biomaterials. LEVEL OF EVIDENCE: Not applicable. Springer International Publishing 2014-10-12 2015-06 /pmc/articles/PMC4441635/ /pubmed/25308902 http://dx.doi.org/10.1007/s10195-014-0323-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Bigham-Sadegh, Amin
Karimi, Iraj
Shadkhast, Mohamad
Mahdavi, Mohamad-Hosein
Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title_full Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title_fullStr Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title_full_unstemmed Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title_short Hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
title_sort hydroxyapatite and demineralized calf fetal growth plate effects on bone healing in rabbit model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441635/
https://www.ncbi.nlm.nih.gov/pubmed/25308902
http://dx.doi.org/10.1007/s10195-014-0323-x
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