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Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis

BACKGROUND: Osteoporosis is a disease, which causes bone loss and fractures. Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis. OBJECTIVES: This study took into consideration the importance of corti...

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Autores principales: Freidouni, Mohammadjavad, Nejati, Hossein, Salimi, Maryam, Bayat, Mohammad, Amini, Abdollah, Noruzian, Mohsen, Asgharie, Mohammad Ali, Rezaian, Milad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441779/
https://www.ncbi.nlm.nih.gov/pubmed/26019900
http://dx.doi.org/10.5812/ircmj.19389
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author Freidouni, Mohammadjavad
Nejati, Hossein
Salimi, Maryam
Bayat, Mohammad
Amini, Abdollah
Noruzian, Mohsen
Asgharie, Mohammad Ali
Rezaian, Milad
author_facet Freidouni, Mohammadjavad
Nejati, Hossein
Salimi, Maryam
Bayat, Mohammad
Amini, Abdollah
Noruzian, Mohsen
Asgharie, Mohammad Ali
Rezaian, Milad
author_sort Freidouni, Mohammadjavad
collection PubMed
description BACKGROUND: Osteoporosis is a disease, which causes bone loss and fractures. Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis. OBJECTIVES: This study took into consideration the importance of cortical bone in the entire bone's mechanical competence. Hence, the aim of this study was to assess the effects of different protocols of glucocorticoid administration on the biomechanical properties of tibial bone diaphysis in rats compared to control and low-level laser-treated rats. MATERIALS AND METHODS: This experimental study was conducted at Shahid Beheshti University of Medical Sciences, Tehran, Iran. We used systematic random sampling to divide 40 adult male rats into 8 groups with 5 rats in each group. Groups were as follows: 1) control, 2) dexamethasone (7 mg/week), 3) dexamethasone (0.7 mg/week), 4) methylprednisolone (7 mg/kg/week), 5) methylprednisolone (5 mg/kg twice weekly), 6) dexamethasone (7 mg/kg three times per week), 7) dexamethasone (0.7 mg/kg thrice per week), and 8) low-level laser-treated rats. The study periods were 4-7 weeks. At the end of the treatment periods, we examined the mechanical properties of tibial bone diaphysis. Data were analyzed by statistical analyses. RESULTS: Glucocorticoid-treated rats showed weight loss and considerable mortality (21%). The biomechanical properties (maximum force) of glucocorticoid-treated rats in groups 4 (62 ± 2.9), 6 (63 ± 5.1), and 7 (60 ± 5.3) were comparable with the control (46 ± 1.5) and low-level laser-treated (57 ± 3.2) rats. CONCLUSIONS: In contrast to the findings in humans and certain other species, glucocorticoid administration caused anabolic effect on the cortical bone of tibia diaphysis bone in rats.
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spelling pubmed-44417792015-05-27 Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis Freidouni, Mohammadjavad Nejati, Hossein Salimi, Maryam Bayat, Mohammad Amini, Abdollah Noruzian, Mohsen Asgharie, Mohammad Ali Rezaian, Milad Iran Red Crescent Med J Research Article BACKGROUND: Osteoporosis is a disease, which causes bone loss and fractures. Although glucocorticoids effectively suppress inflammation, their chronic use is accompanied by bone loss with a tendency toward secondary osteoporosis. OBJECTIVES: This study took into consideration the importance of cortical bone in the entire bone's mechanical competence. Hence, the aim of this study was to assess the effects of different protocols of glucocorticoid administration on the biomechanical properties of tibial bone diaphysis in rats compared to control and low-level laser-treated rats. MATERIALS AND METHODS: This experimental study was conducted at Shahid Beheshti University of Medical Sciences, Tehran, Iran. We used systematic random sampling to divide 40 adult male rats into 8 groups with 5 rats in each group. Groups were as follows: 1) control, 2) dexamethasone (7 mg/week), 3) dexamethasone (0.7 mg/week), 4) methylprednisolone (7 mg/kg/week), 5) methylprednisolone (5 mg/kg twice weekly), 6) dexamethasone (7 mg/kg three times per week), 7) dexamethasone (0.7 mg/kg thrice per week), and 8) low-level laser-treated rats. The study periods were 4-7 weeks. At the end of the treatment periods, we examined the mechanical properties of tibial bone diaphysis. Data were analyzed by statistical analyses. RESULTS: Glucocorticoid-treated rats showed weight loss and considerable mortality (21%). The biomechanical properties (maximum force) of glucocorticoid-treated rats in groups 4 (62 ± 2.9), 6 (63 ± 5.1), and 7 (60 ± 5.3) were comparable with the control (46 ± 1.5) and low-level laser-treated (57 ± 3.2) rats. CONCLUSIONS: In contrast to the findings in humans and certain other species, glucocorticoid administration caused anabolic effect on the cortical bone of tibia diaphysis bone in rats. Kowsar 2015-03-31 /pmc/articles/PMC4441779/ /pubmed/26019900 http://dx.doi.org/10.5812/ircmj.19389 Text en Copyright © 2015, Iranian Red Crescent Medical Journal. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Freidouni, Mohammadjavad
Nejati, Hossein
Salimi, Maryam
Bayat, Mohammad
Amini, Abdollah
Noruzian, Mohsen
Asgharie, Mohammad Ali
Rezaian, Milad
Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title_full Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title_fullStr Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title_full_unstemmed Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title_short Evaluating Glucocorticoid Administration on Biomechanical Properties of Rats’ Tibial Diaphysis
title_sort evaluating glucocorticoid administration on biomechanical properties of rats’ tibial diaphysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441779/
https://www.ncbi.nlm.nih.gov/pubmed/26019900
http://dx.doi.org/10.5812/ircmj.19389
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