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Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients
Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441988/ https://www.ncbi.nlm.nih.gov/pubmed/26064774 http://dx.doi.org/10.1155/2015/734857 |
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author | Zampieri, Fernando G. Jacob, Vanessa Barbeiro, Hermes V. Pinheiro da Silva, Fabiano de Souza, Heraldo P. |
author_facet | Zampieri, Fernando G. Jacob, Vanessa Barbeiro, Hermes V. Pinheiro da Silva, Fabiano de Souza, Heraldo P. |
author_sort | Zampieri, Fernando G. |
collection | PubMed |
description | Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings. |
format | Online Article Text |
id | pubmed-4441988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44419882015-06-10 Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients Zampieri, Fernando G. Jacob, Vanessa Barbeiro, Hermes V. Pinheiro da Silva, Fabiano de Souza, Heraldo P. Int J Inflam Research Article Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings. Hindawi Publishing Corporation 2015 2015-05-10 /pmc/articles/PMC4441988/ /pubmed/26064774 http://dx.doi.org/10.1155/2015/734857 Text en Copyright © 2015 Fernando G. Zampieri et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zampieri, Fernando G. Jacob, Vanessa Barbeiro, Hermes V. Pinheiro da Silva, Fabiano de Souza, Heraldo P. Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title_full | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title_fullStr | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title_full_unstemmed | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title_short | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
title_sort | influence of body mass index on inflammatory profile at admission in critically ill septic patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441988/ https://www.ncbi.nlm.nih.gov/pubmed/26064774 http://dx.doi.org/10.1155/2015/734857 |
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