Interaction of H(2)S with Calcium Permeable Channels and Transporters

A growing amount of evidence has suggested that hydrogen sulfide (H(2)S), as a gasotransmitter, is involved in intensive physiological and pathological processes. More and more research groups have found that H(2)S mediates diverse cellular biological functions related to regulating intracellular calcium concentration. These groups have demonstrated the reciprocal interaction between H(2)S and calcium ion channels and transporters, such as L-type calcium channels (LTCC), T-type calcium channels (TTCC), sodium/calcium exchangers (NCX), transient receptor potential (TRP) channels, β-adrenergic receptors, and N-methyl-D-aspartate receptors (NMDAR) in different cells. However, the understanding of the molecular targets and mechanisms is incomplete. Recently, some research groups demonstrated that H(2)S modulates the activity of calcium ion channels through protein S-sulfhydration and polysulfide reactions. In this review, we elucidate that H(2)S controls intracellular calcium homeostasis and the underlying mechanisms.