An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

Hydrogen sulfide (H(2)S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Qi, Qi, Yang, Jianqiang, Sun, Dongsheng, Li, Chunfeng, Xue, Yingwei, Jiang, Qiuying, Tian, Ye, Xu, Changqing, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442311/
https://www.ncbi.nlm.nih.gov/pubmed/26078811
http://dx.doi.org/10.1155/2015/636410
Descripción
Sumario:Hydrogen sulfide (H(2)S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H(2)S is thus indicated.

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