An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

Hydrogen sulfide (H(2)S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and...

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Autores principales: Zhang, Li, Qi, Qi, Yang, Jianqiang, Sun, Dongsheng, Li, Chunfeng, Xue, Yingwei, Jiang, Qiuying, Tian, Ye, Xu, Changqing, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442311/
https://www.ncbi.nlm.nih.gov/pubmed/26078811
http://dx.doi.org/10.1155/2015/636410
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author Zhang, Li
Qi, Qi
Yang, Jianqiang
Sun, Dongsheng
Li, Chunfeng
Xue, Yingwei
Jiang, Qiuying
Tian, Ye
Xu, Changqing
Wang, Rui
author_facet Zhang, Li
Qi, Qi
Yang, Jianqiang
Sun, Dongsheng
Li, Chunfeng
Xue, Yingwei
Jiang, Qiuying
Tian, Ye
Xu, Changqing
Wang, Rui
author_sort Zhang, Li
collection PubMed
description Hydrogen sulfide (H(2)S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H(2)S is thus indicated.
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spelling pubmed-44423112015-06-15 An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells Zhang, Li Qi, Qi Yang, Jianqiang Sun, Dongsheng Li, Chunfeng Xue, Yingwei Jiang, Qiuying Tian, Ye Xu, Changqing Wang, Rui Oxid Med Cell Longev Research Article Hydrogen sulfide (H(2)S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H(2)S is thus indicated. Hindawi Publishing Corporation 2015 2015-05-11 /pmc/articles/PMC4442311/ /pubmed/26078811 http://dx.doi.org/10.1155/2015/636410 Text en Copyright © 2015 Li Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Li
Qi, Qi
Yang, Jianqiang
Sun, Dongsheng
Li, Chunfeng
Xue, Yingwei
Jiang, Qiuying
Tian, Ye
Xu, Changqing
Wang, Rui
An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title_full An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title_fullStr An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title_full_unstemmed An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title_short An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
title_sort anticancer role of hydrogen sulfide in human gastric cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442311/
https://www.ncbi.nlm.nih.gov/pubmed/26078811
http://dx.doi.org/10.1155/2015/636410
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