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Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model

During the last century, vitamin A has evolved from its classical role as a fat-soluble vitamin and attained the status of para-/autocrine hormone. Besides its well-established role in embryogenesis, growth and development, reproduction and vision, vitamin A has also been implicated in several other...

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Autores principales: Jeyakumar, Shanmugam M., Vajreswari, Ayyalasomayajula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442325/
https://www.ncbi.nlm.nih.gov/pubmed/25963488
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author Jeyakumar, Shanmugam M.
Vajreswari, Ayyalasomayajula
author_facet Jeyakumar, Shanmugam M.
Vajreswari, Ayyalasomayajula
author_sort Jeyakumar, Shanmugam M.
collection PubMed
description During the last century, vitamin A has evolved from its classical role as a fat-soluble vitamin and attained the status of para-/autocrine hormone. Besides its well-established role in embryogenesis, growth and development, reproduction and vision, vitamin A has also been implicated in several other physiological processes. Emerging experimental evidences emphasize adipose tissue as an active endocrine organ with great propensity to continuous growth (throughout life). Due to various genetic and lifestyle factors, excess energy accumulates in adipose tissue as fat, resulting in obesity and other complications such as type 2 diabetes, hypertension, and cardiovascular disease. Recent in vitro and in vivo studies have shed light on vitamin A metabolites; retinaldehyde and retinoic acid and participation of their pathway proteins in the regulation of adipose tissue metabolism and thus, obesity. In this context, we discuss here some of our important findings, which establish the role of vitamin A (supplementation) in obesity and its associated disorders by employing an obese rat model; WNIN/Ob strain.
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spelling pubmed-44423252015-05-25 Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model Jeyakumar, Shanmugam M. Vajreswari, Ayyalasomayajula Indian J Med Res Review Article During the last century, vitamin A has evolved from its classical role as a fat-soluble vitamin and attained the status of para-/autocrine hormone. Besides its well-established role in embryogenesis, growth and development, reproduction and vision, vitamin A has also been implicated in several other physiological processes. Emerging experimental evidences emphasize adipose tissue as an active endocrine organ with great propensity to continuous growth (throughout life). Due to various genetic and lifestyle factors, excess energy accumulates in adipose tissue as fat, resulting in obesity and other complications such as type 2 diabetes, hypertension, and cardiovascular disease. Recent in vitro and in vivo studies have shed light on vitamin A metabolites; retinaldehyde and retinoic acid and participation of their pathway proteins in the regulation of adipose tissue metabolism and thus, obesity. In this context, we discuss here some of our important findings, which establish the role of vitamin A (supplementation) in obesity and its associated disorders by employing an obese rat model; WNIN/Ob strain. Medknow Publications & Media Pvt Ltd 2015-03 /pmc/articles/PMC4442325/ /pubmed/25963488 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jeyakumar, Shanmugam M.
Vajreswari, Ayyalasomayajula
Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title_full Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title_fullStr Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title_full_unstemmed Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title_short Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
title_sort vitamin a as a key regulator of obesity & its associated disorders: evidences from an obese rat model
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442325/
https://www.ncbi.nlm.nih.gov/pubmed/25963488
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