First data on Pneumocystis jirovecii colonization in patients with respiratory diseases in North Lebanon

Pneumocystis colonization may play a role in transmission and local inflammatory response. It was explored in patients with respiratory diseases in North Lebanon. Overall prevalence reached only 5.2% (95% CI 2.13–10.47) but it was higher (17.3%) in the subpopulation of patients with chronic obstruct...

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Detalles Bibliográficos
Autores principales: Khalife, S., Aliouat, E.M., Aliouat-Denis, C.M., Gantois, N., Devos, P., Mallat, H., Dei-Cas, E., Dabboussi, F., Hamze, M., Fréalle, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
New Microbes in Humans
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442690/
https://www.ncbi.nlm.nih.gov/pubmed/26042187
http://dx.doi.org/10.1016/j.nmni.2015.02.006
Descripción
Sumario:Pneumocystis colonization may play a role in transmission and local inflammatory response. It was explored in patients with respiratory diseases in North Lebanon. Overall prevalence reached only 5.2% (95% CI 2.13–10.47) but it was higher (17.3%) in the subpopulation of patients with chronic obstructive pulmonary disease (COPD). COPD was the only factor associated with a significantly increased risk of colonization. mtLSU genotyping revealed predominance of genotype 2, identified in five patients (71.4%), including one patient who had co-infection with genotype 3. These first data in North Lebanon confirm Pneumocystis circulation among patients with respiratory diseases and the potential for transmission to immunocompromised patients.

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