Cargando…

Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial

OBJECTIVE: To evaluate the role of oral pentoxifylline for enhancing the recovery of erectile function (EF) in patients who had a T-shunt, a technically simple procedure for treating prolonged ischaemic priapism, as the recovery of EF has been reported in many patients treated by this procedure. PAT...

Descripción completa

Detalles Bibliográficos
Autores principales: Zahran, Abdel-Rahman, Abdel Daiem, Hussein, Youssif, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442918/
https://www.ncbi.nlm.nih.gov/pubmed/26558062
http://dx.doi.org/10.1016/j.aju.2012.05.006
_version_ 1782372940136841216
author Zahran, Abdel-Rahman
Abdel Daiem, Hussein
Youssif, Mohamed
author_facet Zahran, Abdel-Rahman
Abdel Daiem, Hussein
Youssif, Mohamed
author_sort Zahran, Abdel-Rahman
collection PubMed
description OBJECTIVE: To evaluate the role of oral pentoxifylline for enhancing the recovery of erectile function (EF) in patients who had a T-shunt, a technically simple procedure for treating prolonged ischaemic priapism, as the recovery of EF has been reported in many patients treated by this procedure. PATIENTS AND METHODS: This prospective randomised study was conducted on 40 patients with prolonged ischaemic priapism treated with a T-shunt. Patients were randomly divided into two groups; group A received oral pentoxifylline from the second day after surgery for 3 months, and group B received placebo. Patients were followed for 18 months. RESULTS: The pain resolved in all patients, and EF recovered in 15 patients in group A and 10 in group B within 3 months. All patients but three had recovery of EF within the 18-month follow-up. Six patients had recovery of EF by using on-demand 50 mg sildenafil. The three patients who did not recover EF had a penile prosthesis implanted after the end of the study. CONCLUSION: Pentoxifylline had no significant effect on the recovery of EF after a T-shunt procedure, but a larger study (double-blinded) is required for a more accurate assessment of any beneficial effect of pentoxifylline after a T-shunt procedure.
format Online
Article
Text
id pubmed-4442918
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-44429182015-11-10 Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial Zahran, Abdel-Rahman Abdel Daiem, Hussein Youssif, Mohamed Arab J Urol Andrology/Sexual Medicine Original Article OBJECTIVE: To evaluate the role of oral pentoxifylline for enhancing the recovery of erectile function (EF) in patients who had a T-shunt, a technically simple procedure for treating prolonged ischaemic priapism, as the recovery of EF has been reported in many patients treated by this procedure. PATIENTS AND METHODS: This prospective randomised study was conducted on 40 patients with prolonged ischaemic priapism treated with a T-shunt. Patients were randomly divided into two groups; group A received oral pentoxifylline from the second day after surgery for 3 months, and group B received placebo. Patients were followed for 18 months. RESULTS: The pain resolved in all patients, and EF recovered in 15 patients in group A and 10 in group B within 3 months. All patients but three had recovery of EF within the 18-month follow-up. Six patients had recovery of EF by using on-demand 50 mg sildenafil. The three patients who did not recover EF had a penile prosthesis implanted after the end of the study. CONCLUSION: Pentoxifylline had no significant effect on the recovery of EF after a T-shunt procedure, but a larger study (double-blinded) is required for a more accurate assessment of any beneficial effect of pentoxifylline after a T-shunt procedure. Elsevier 2012-12 2012-07-17 /pmc/articles/PMC4442918/ /pubmed/26558062 http://dx.doi.org/10.1016/j.aju.2012.05.006 Text en © 2012 Arab Association of Urology. Production and hosting by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Andrology/Sexual Medicine Original Article
Zahran, Abdel-Rahman
Abdel Daiem, Hussein
Youssif, Mohamed
Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title_full Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title_fullStr Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title_full_unstemmed Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title_short Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial
title_sort does pentoxifylline enhance the recovery of erectile function after a t-shunt procedure for prolonged ischaemic priapism? a prospective randomised controlled trial
topic Andrology/Sexual Medicine Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442918/
https://www.ncbi.nlm.nih.gov/pubmed/26558062
http://dx.doi.org/10.1016/j.aju.2012.05.006
work_keys_str_mv AT zahranabdelrahman doespentoxifyllineenhancetherecoveryoferectilefunctionafteratshuntprocedureforprolongedischaemicpriapismaprospectiverandomisedcontrolledtrial
AT abdeldaiemhussein doespentoxifyllineenhancetherecoveryoferectilefunctionafteratshuntprocedureforprolongedischaemicpriapismaprospectiverandomisedcontrolledtrial
AT youssifmohamed doespentoxifyllineenhancetherecoveryoferectilefunctionafteratshuntprocedureforprolongedischaemicpriapismaprospectiverandomisedcontrolledtrial