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Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of a...

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Autores principales: Nah, Jihoon, Yuan, Junying, Jung, Yong-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443278/
https://www.ncbi.nlm.nih.gov/pubmed/25896254
http://dx.doi.org/10.14348/molcells.2015.0034
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author Nah, Jihoon
Yuan, Junying
Jung, Yong-Keun
author_facet Nah, Jihoon
Yuan, Junying
Jung, Yong-Keun
author_sort Nah, Jihoon
collection PubMed
description Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of autophagy can lead to cellular dysfunction and diseases. Accumulation of abnormal protein aggregates, a common cause of neurodegenerative diseases, can be reduced through autophagic degradation. Recent studies have revealed defects in autophagy in most cases of neurodegenerative disorders. Moreover, deregulated excessive autophagy can also cause neurodegeneration. Thus, healthy activation of autophagy is essential for therapeutic approaches in neurodegenerative diseases and many autophagy-regulating compounds are under development for therapeutic purposes. This review describes the overall role of autophagy in neurodegeneration, focusing on various therapeutic strategies for modulating specific stages of autophagy and on the current status of drug development.
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spelling pubmed-44432782015-06-01 Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach Nah, Jihoon Yuan, Junying Jung, Yong-Keun Mol Cells Minireview Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of autophagy can lead to cellular dysfunction and diseases. Accumulation of abnormal protein aggregates, a common cause of neurodegenerative diseases, can be reduced through autophagic degradation. Recent studies have revealed defects in autophagy in most cases of neurodegenerative disorders. Moreover, deregulated excessive autophagy can also cause neurodegeneration. Thus, healthy activation of autophagy is essential for therapeutic approaches in neurodegenerative diseases and many autophagy-regulating compounds are under development for therapeutic purposes. This review describes the overall role of autophagy in neurodegeneration, focusing on various therapeutic strategies for modulating specific stages of autophagy and on the current status of drug development. Korean Society for Molecular and Cellular Biology 2015-05-31 2015-04-20 /pmc/articles/PMC4443278/ /pubmed/25896254 http://dx.doi.org/10.14348/molcells.2015.0034 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Minireview
Nah, Jihoon
Yuan, Junying
Jung, Yong-Keun
Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title_full Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title_fullStr Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title_full_unstemmed Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title_short Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
title_sort autophagy in neurodegenerative diseases: from mechanism to therapeutic approach
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443278/
https://www.ncbi.nlm.nih.gov/pubmed/25896254
http://dx.doi.org/10.14348/molcells.2015.0034
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