Ghrelin

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE O...

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Detalles Bibliográficos
Autores principales: Müller, T.D., Nogueiras, R., Andermann, M.L., Andrews, Z.B., Anker, S.D., Argente, J., Batterham, R.L., Benoit, S.C., Bowers, C.Y., Broglio, F., Casanueva, F.F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P.A., Cowley, M., Cummings, D.E., Dagher, A., Diano, S., Dickson, S.L., Diéguez, C., Granata, R., Grill, H.J., Grove, K., Habegger, K.M., Heppner, K., Heiman, M.L., Holsen, L., Holst, B., Inui, A., Jansson, J.O., Kirchner, H., Korbonits, M., Laferrère, B., LeRoux, C.W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P.T., Schwartz, T.W., Seeley, R.J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M.O., van der Lely, A.J., van der Ploeg, L.H.T., Zigman, J.M., Kojima, M., Kangawa, K., Smith, R.G., Horvath, T., Tschöp, M.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443295/
https://www.ncbi.nlm.nih.gov/pubmed/26042199
http://dx.doi.org/10.1016/j.molmet.2015.03.005
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author Müller, T.D.
Nogueiras, R.
Andermann, M.L.
Andrews, Z.B.
Anker, S.D.
Argente, J.
Batterham, R.L.
Benoit, S.C.
Bowers, C.Y.
Broglio, F.
Casanueva, F.F.
D'Alessio, D.
Depoortere, I.
Geliebter, A.
Ghigo, E.
Cole, P.A.
Cowley, M.
Cummings, D.E.
Dagher, A.
Diano, S.
Dickson, S.L.
Diéguez, C.
Granata, R.
Grill, H.J.
Grove, K.
Habegger, K.M.
Heppner, K.
Heiman, M.L.
Holsen, L.
Holst, B.
Inui, A.
Jansson, J.O.
Kirchner, H.
Korbonits, M.
Laferrère, B.
LeRoux, C.W.
Lopez, M.
Morin, S.
Nakazato, M.
Nass, R.
Perez-Tilve, D.
Pfluger, P.T.
Schwartz, T.W.
Seeley, R.J.
Sleeman, M.
Sun, Y.
Sussel, L.
Tong, J.
Thorner, M.O.
van der Lely, A.J.
van der Ploeg, L.H.T.
Zigman, J.M.
Kojima, M.
Kangawa, K.
Smith, R.G.
Horvath, T.
Tschöp, M.H.
author_facet Müller, T.D.
Nogueiras, R.
Andermann, M.L.
Andrews, Z.B.
Anker, S.D.
Argente, J.
Batterham, R.L.
Benoit, S.C.
Bowers, C.Y.
Broglio, F.
Casanueva, F.F.
D'Alessio, D.
Depoortere, I.
Geliebter, A.
Ghigo, E.
Cole, P.A.
Cowley, M.
Cummings, D.E.
Dagher, A.
Diano, S.
Dickson, S.L.
Diéguez, C.
Granata, R.
Grill, H.J.
Grove, K.
Habegger, K.M.
Heppner, K.
Heiman, M.L.
Holsen, L.
Holst, B.
Inui, A.
Jansson, J.O.
Kirchner, H.
Korbonits, M.
Laferrère, B.
LeRoux, C.W.
Lopez, M.
Morin, S.
Nakazato, M.
Nass, R.
Perez-Tilve, D.
Pfluger, P.T.
Schwartz, T.W.
Seeley, R.J.
Sleeman, M.
Sun, Y.
Sussel, L.
Tong, J.
Thorner, M.O.
van der Lely, A.J.
van der Ploeg, L.H.T.
Zigman, J.M.
Kojima, M.
Kangawa, K.
Smith, R.G.
Horvath, T.
Tschöp, M.H.
author_sort Müller, T.D.
collection PubMed
description BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
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spelling pubmed-44432952015-06-03 Ghrelin Müller, T.D. Nogueiras, R. Andermann, M.L. Andrews, Z.B. Anker, S.D. Argente, J. Batterham, R.L. Benoit, S.C. Bowers, C.Y. Broglio, F. Casanueva, F.F. D'Alessio, D. Depoortere, I. Geliebter, A. Ghigo, E. Cole, P.A. Cowley, M. Cummings, D.E. Dagher, A. Diano, S. Dickson, S.L. Diéguez, C. Granata, R. Grill, H.J. Grove, K. Habegger, K.M. Heppner, K. Heiman, M.L. Holsen, L. Holst, B. Inui, A. Jansson, J.O. Kirchner, H. Korbonits, M. Laferrère, B. LeRoux, C.W. Lopez, M. Morin, S. Nakazato, M. Nass, R. Perez-Tilve, D. Pfluger, P.T. Schwartz, T.W. Seeley, R.J. Sleeman, M. Sun, Y. Sussel, L. Tong, J. Thorner, M.O. van der Lely, A.J. van der Ploeg, L.H.T. Zigman, J.M. Kojima, M. Kangawa, K. Smith, R.G. Horvath, T. Tschöp, M.H. Mol Metab Minireview BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism. Elsevier 2015-03-21 /pmc/articles/PMC4443295/ /pubmed/26042199 http://dx.doi.org/10.1016/j.molmet.2015.03.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Minireview
Müller, T.D.
Nogueiras, R.
Andermann, M.L.
Andrews, Z.B.
Anker, S.D.
Argente, J.
Batterham, R.L.
Benoit, S.C.
Bowers, C.Y.
Broglio, F.
Casanueva, F.F.
D'Alessio, D.
Depoortere, I.
Geliebter, A.
Ghigo, E.
Cole, P.A.
Cowley, M.
Cummings, D.E.
Dagher, A.
Diano, S.
Dickson, S.L.
Diéguez, C.
Granata, R.
Grill, H.J.
Grove, K.
Habegger, K.M.
Heppner, K.
Heiman, M.L.
Holsen, L.
Holst, B.
Inui, A.
Jansson, J.O.
Kirchner, H.
Korbonits, M.
Laferrère, B.
LeRoux, C.W.
Lopez, M.
Morin, S.
Nakazato, M.
Nass, R.
Perez-Tilve, D.
Pfluger, P.T.
Schwartz, T.W.
Seeley, R.J.
Sleeman, M.
Sun, Y.
Sussel, L.
Tong, J.
Thorner, M.O.
van der Lely, A.J.
van der Ploeg, L.H.T.
Zigman, J.M.
Kojima, M.
Kangawa, K.
Smith, R.G.
Horvath, T.
Tschöp, M.H.
Ghrelin
title Ghrelin
title_full Ghrelin
title_fullStr Ghrelin
title_full_unstemmed Ghrelin
title_short Ghrelin
title_sort ghrelin
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443295/
https://www.ncbi.nlm.nih.gov/pubmed/26042199
http://dx.doi.org/10.1016/j.molmet.2015.03.005
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