Cargando…

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant Trypanosoma brucei gambiense isolates from sleeping...

Descripción completa

Detalles Bibliográficos
Autores principales:	Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443405/ https://www.ncbi.nlm.nih.gov/pubmed/26042196 http://dx.doi.org/10.1016/j.ijpddr.2015.04.002

Ejemplares similares

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
por: Graf, Fabrice E., et al.
Publicado: (2013)

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei
por: Alghamdi, Ali H, et al.
Publicado: (2020)

Genotypic Status of the TbAT1/P2 Adenosine Transporter of Trypanosoma brucei gambiense Isolates from Northwestern Uganda following Melarsoprol Withdrawal
por: Kazibwe, Anne J. N., et al.
Publicado: (2009)

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei
por: Quintana, Juan F., et al.
Publicado: (2020)

Melarsoprol Sensitivity Profile of Trypanosoma brucei gambiense Isolates from Cured and Relapsed Sleeping Sickness Patients from the Democratic Republic of the Congo
por: Pyana Pati, Patient, et al.
Publicado: (2014)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
por: Munday, Jane C., et al.
Publicado: (2014)

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
por: Graf, Fabrice E., et al.
Publicado: (2016)

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2
por: Song, Jie, et al.
Publicado: (2016)

Luminescent multiplex viability assay for Trypanosoma brucei gambiense
por: Van Reet, Nick, et al.
Publicado: (2013)

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity()
por: Lüscher, Alexandra, et al.
Publicado: (2013)

Immunohistochemical Localization of the Aquaporins AQP1, AQP3, AQP4, and AQP5 in the Mouse Respiratory System
por: Matsuzaki, Toshiyuki, et al.
Publicado: (2009)

Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal
por: Jamonneau, Vincent, et al.
Publicado: (2012)

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
por: Umeakuana, Paschal Ugochukwu, et al.
Publicado: (2019)

Target product profile: diagnostic test for Trypanosoma brucei gambiense
por: Priotto, Gerardo, et al.
Publicado: (2023)

Recombinant Antigens Expressed in Pichia pastoris for the Diagnosis of Sleeping Sickness Caused by Trypanosoma brucei gambiense
por: Rogé, Stijn, et al.
Publicado: (2014)

Identification of Peptide Mimotopes of Trypanosoma brucei gambiense Variant Surface Glycoproteins
por: Van Nieuwenhove, Liesbeth Carolien, et al.
Publicado: (2011)

Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections
por: Bucheton, B, et al.
Publicado: (2011)

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense
por: Cooper, Anneli, et al.
Publicado: (2016)

Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus
por: Tesoriero, Chiara, et al.
Publicado: (2018)

Target product profile: Trypanosoma brucei gambiense test to verify elimination
por: Priotto, Gerardo, et al.
Publicado: (2023)

A Trypanosoma brucei ORFeome-Based Gain-of-Function Library Identifies Genes That Promote Survival during Melarsoprol Treatment
por: Carter, McKenzie, et al.
Publicado: (2020)

AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
por: Trillo-Contreras, José Luis, et al.
Publicado: (2019)

The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambiense
por: Capewell, Paul, et al.
Publicado: (2013)

Target product profile: Trypanosoma brucei gambiense test for low-prevalence settings
por: Priotto, Gerardo, et al.
Publicado: (2023)

Association of Genetic Variation at AQP4 Locus with Vascular Depression
por: Westermair, Anna L., et al.
Publicado: (2018)

The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis
por: Jackson, Andrew P., et al.
Publicado: (2010)

Specificity of malaria rapid diagnostic tests is affected by Trypanosoma brucei gambiense sleeping sickness
por: Gillet, Philippe, et al.
Publicado: (2012)

The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected
por: Mehlitz, D., et al.
Publicado: (2019)

Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance
por: Wang, Wei, et al.
Publicado: (2012)

Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys
por: Fu, Yu, et al.
Publicado: (2019)

AQP3 and AQP5—Potential Regulators of Redox Status in Breast Cancer
por: Milković, Lidija, et al.
Publicado: (2021)

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei
por: Munday, Jane C., et al.
Publicado: (2015)

Immunohistochemical Localization of the Water Channels AQP4 and AQP5 in the Rat Pituitary Gland
por: Matsuzaki, Toshiyuki, et al.
Publicado: (2011)

AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation
por: Arnspang, Eva C., et al.
Publicado: (2016)

Changes in the Expression of AQP4 and AQP9 in the Hippocampus Following Eclampsia-Like Seizure
por: Han, Xinjia, et al.
Publicado: (2018)

The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
por: Zhao, Zitong, et al.
Publicado: (2022)

AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation
por: Rump, Katharina, et al.
Publicado: (2022)

NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
por: Yun, Oliver, et al.
Publicado: (2010)

Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness
por: Tiberti, Natalia, et al.
Publicado: (2012)

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity
por: Cordon-Obras, Carlos, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6p7kanrt531d5efrjcb8goeh1l