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Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs

BACKGROUND: Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and show an accumulation of genomic scars in the form of gross DNA copy number aberrations. Cancers without BRCA1 or BRCA2 loss b...

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Detalles Bibliográficos
Autores principales:	Marquard, Andrea M, Eklund, Aron C, Joshi, Tejal, Krzystanek, Marcin, Favero, Francesco, Wang, Zhigang C, Richardson, Andrea L, Silver, Daniel P, Szallasi, Zoltan, Birkbak, Nicolai J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443545/ https://www.ncbi.nlm.nih.gov/pubmed/26015868 http://dx.doi.org/10.1186/s40364-015-0033-4

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