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Is mouse embryonic stem cell technology obsolete?
Injection of recombinant Cas9 protein and synthetic guide RNAs into mouse zygotes has been shown to facilitate gene disruption and knock-ins using the CRISPR system. These technologies may soon displace genetic modification using embryonic stem cells.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443626/ https://www.ncbi.nlm.nih.gov/pubmed/26013980 http://dx.doi.org/10.1186/s13059-015-0673-6 |
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| author | Skarnes, William C |
| author_facet | Skarnes, William C |
| author_sort | Skarnes, William C |
| collection | PubMed |
| description | Injection of recombinant Cas9 protein and synthetic guide RNAs into mouse zygotes has been shown to facilitate gene disruption and knock-ins using the CRISPR system. These technologies may soon displace genetic modification using embryonic stem cells. |
| format | Online Article Text |
| id | pubmed-4443626 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44436262015-05-27 Is mouse embryonic stem cell technology obsolete? Skarnes, William C Genome Biol Research Highlight Injection of recombinant Cas9 protein and synthetic guide RNAs into mouse zygotes has been shown to facilitate gene disruption and knock-ins using the CRISPR system. These technologies may soon displace genetic modification using embryonic stem cells. BioMed Central 2015-05-27 2015 /pmc/articles/PMC4443626/ /pubmed/26013980 http://dx.doi.org/10.1186/s13059-015-0673-6 Text en © Skarnes; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Research Highlight Skarnes, William C Is mouse embryonic stem cell technology obsolete? |
| title | Is mouse embryonic stem cell technology obsolete? |
| title_full | Is mouse embryonic stem cell technology obsolete? |
| title_fullStr | Is mouse embryonic stem cell technology obsolete? |
| title_full_unstemmed | Is mouse embryonic stem cell technology obsolete? |
| title_short | Is mouse embryonic stem cell technology obsolete? |
| title_sort | is mouse embryonic stem cell technology obsolete? |
| topic | Research Highlight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443626/ https://www.ncbi.nlm.nih.gov/pubmed/26013980 http://dx.doi.org/10.1186/s13059-015-0673-6 |
| work_keys_str_mv | AT skarneswilliamc ismouseembryonicstemcelltechnologyobsolete |