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Is mouse embryonic stem cell technology obsolete?
Injection of recombinant Cas9 protein and synthetic guide RNAs into mouse zygotes has been shown to facilitate gene disruption and knock-ins using the CRISPR system. These technologies may soon displace genetic modification using embryonic stem cells.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443626/ https://www.ncbi.nlm.nih.gov/pubmed/26013980 http://dx.doi.org/10.1186/s13059-015-0673-6 |