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Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines

BACKGROUND: There has been considerable progress in the management of acute lymphoblastic leukemia (ALL) but further improvement is needed to increase long-term survival. The thiopurine agent 6-mercaptopurine (6-MP) used for ALL maintenance therapy has a key influence on clinical outcomes and relaps...

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Detalles Bibliográficos
Autores principales:	Chouchana, Laurent, Fernández-Ramos, Ana Aurora, Dumont, Florent, Marchetti, Catherine, Ceballos-Picot, Irène, Beaune, Philippe, Gurwitz, David, Loriot, Marie-Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443628/ https://www.ncbi.nlm.nih.gov/pubmed/26015807 http://dx.doi.org/10.1186/s13073-015-0150-6

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