Cargando…
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period
BACKGROUND: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443632/ https://www.ncbi.nlm.nih.gov/pubmed/25990414 http://dx.doi.org/10.1186/s12902-015-0012-7 |
_version_ | 1782373025143848960 |
---|---|
author | Biason, Talita Poli Goldberg, Tamara Beres Lederer Kurokawa, Cilmery Suemi Moretto, Maria Regina Teixeira, Altamir Santos Nunes, Hélio Rubens de Carvalho |
author_facet | Biason, Talita Poli Goldberg, Tamara Beres Lederer Kurokawa, Cilmery Suemi Moretto, Maria Regina Teixeira, Altamir Santos Nunes, Hélio Rubens de Carvalho |
author_sort | Biason, Talita Poli |
collection | PubMed |
description | BACKGROUND: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs. METHODS: This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 μg ethinylestradiol/150 μg desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann–Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables. RESULTS: The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users. CONCLUSIONS: Use of a low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) was associated with lower bone mass acquisition in adolescents during the study period. TRIAL REGISTRATION: Registry Number, RBR-5h9b3c. |
format | Online Article Text |
id | pubmed-4443632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44436322015-05-27 Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period Biason, Talita Poli Goldberg, Tamara Beres Lederer Kurokawa, Cilmery Suemi Moretto, Maria Regina Teixeira, Altamir Santos Nunes, Hélio Rubens de Carvalho BMC Endocr Disord Research Article BACKGROUND: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs. METHODS: This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 μg ethinylestradiol/150 μg desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann–Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables. RESULTS: The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users. CONCLUSIONS: Use of a low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) was associated with lower bone mass acquisition in adolescents during the study period. TRIAL REGISTRATION: Registry Number, RBR-5h9b3c. BioMed Central 2015-04-03 /pmc/articles/PMC4443632/ /pubmed/25990414 http://dx.doi.org/10.1186/s12902-015-0012-7 Text en © Biason et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Biason, Talita Poli Goldberg, Tamara Beres Lederer Kurokawa, Cilmery Suemi Moretto, Maria Regina Teixeira, Altamir Santos Nunes, Hélio Rubens de Carvalho Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title | Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_full | Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_fullStr | Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_full_unstemmed | Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_short | Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_sort | low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443632/ https://www.ncbi.nlm.nih.gov/pubmed/25990414 http://dx.doi.org/10.1186/s12902-015-0012-7 |
work_keys_str_mv | AT biasontalitapoli lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod AT goldbergtamarabereslederer lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod AT kurokawacilmerysuemi lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod AT morettomariaregina lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod AT teixeiraaltamirsantos lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod AT nunesheliorubensdecarvalho lowdosecombinedoralcontraceptiveuseisassociatedwithlowerbonemineralcontentvariationinadolescentsovera1yearperiod |