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Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia

BACKGROUND: DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at R882 in the methyltransferase domain o...

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Detalles Bibliográficos
Autores principales:	Berenstein, Rimma, Blau, Igor Wolfgang, Suckert, Nikola, Baldus, Claudia, Pezzutto, Antonio, Dörken, Bernd, Blau, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443651/ https://www.ncbi.nlm.nih.gov/pubmed/25994761 http://dx.doi.org/10.1186/s13046-015-0173-2

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