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The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients

Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occ...

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Autores principales: Chen, Chih-Jen, Tang, Kuo-Shu, Huang, Ying-Hsien, Chen, Chao-Long, Huang, Li-Tung, Chuang, Jiin-Haur, Tiao, Mao-Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443700/
https://www.ncbi.nlm.nih.gov/pubmed/26064908
http://dx.doi.org/10.1155/2015/421413
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author Chen, Chih-Jen
Tang, Kuo-Shu
Huang, Ying-Hsien
Chen, Chao-Long
Huang, Li-Tung
Chuang, Jiin-Haur
Tiao, Mao-Meng
author_facet Chen, Chih-Jen
Tang, Kuo-Shu
Huang, Ying-Hsien
Chen, Chao-Long
Huang, Li-Tung
Chuang, Jiin-Haur
Tiao, Mao-Meng
author_sort Chen, Chih-Jen
collection PubMed
description Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). Methods. We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed. Results. The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group. Conclusions. These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.
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spelling pubmed-44437002015-06-10 The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients Chen, Chih-Jen Tang, Kuo-Shu Huang, Ying-Hsien Chen, Chao-Long Huang, Li-Tung Chuang, Jiin-Haur Tiao, Mao-Meng Biomed Res Int Research Article Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). Methods. We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed. Results. The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group. Conclusions. These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA. Hindawi Publishing Corporation 2015 2015-05-12 /pmc/articles/PMC4443700/ /pubmed/26064908 http://dx.doi.org/10.1155/2015/421413 Text en Copyright © 2015 Chih-Jen Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Chih-Jen
Tang, Kuo-Shu
Huang, Ying-Hsien
Chen, Chao-Long
Huang, Li-Tung
Chuang, Jiin-Haur
Tiao, Mao-Meng
The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title_full The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title_fullStr The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title_full_unstemmed The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title_short The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
title_sort characteristics of antioxidant activity after liver transplantation in biliary atresia patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443700/
https://www.ncbi.nlm.nih.gov/pubmed/26064908
http://dx.doi.org/10.1155/2015/421413
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