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The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients
Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occ...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443700/ https://www.ncbi.nlm.nih.gov/pubmed/26064908 http://dx.doi.org/10.1155/2015/421413 |
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author | Chen, Chih-Jen Tang, Kuo-Shu Huang, Ying-Hsien Chen, Chao-Long Huang, Li-Tung Chuang, Jiin-Haur Tiao, Mao-Meng |
author_facet | Chen, Chih-Jen Tang, Kuo-Shu Huang, Ying-Hsien Chen, Chao-Long Huang, Li-Tung Chuang, Jiin-Haur Tiao, Mao-Meng |
author_sort | Chen, Chih-Jen |
collection | PubMed |
description | Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). Methods. We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed. Results. The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group. Conclusions. These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA. |
format | Online Article Text |
id | pubmed-4443700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44437002015-06-10 The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients Chen, Chih-Jen Tang, Kuo-Shu Huang, Ying-Hsien Chen, Chao-Long Huang, Li-Tung Chuang, Jiin-Haur Tiao, Mao-Meng Biomed Res Int Research Article Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). Methods. We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed. Results. The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group. Conclusions. These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA. Hindawi Publishing Corporation 2015 2015-05-12 /pmc/articles/PMC4443700/ /pubmed/26064908 http://dx.doi.org/10.1155/2015/421413 Text en Copyright © 2015 Chih-Jen Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Chih-Jen Tang, Kuo-Shu Huang, Ying-Hsien Chen, Chao-Long Huang, Li-Tung Chuang, Jiin-Haur Tiao, Mao-Meng The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title | The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title_full | The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title_fullStr | The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title_full_unstemmed | The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title_short | The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients |
title_sort | characteristics of antioxidant activity after liver transplantation in biliary atresia patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443700/ https://www.ncbi.nlm.nih.gov/pubmed/26064908 http://dx.doi.org/10.1155/2015/421413 |
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