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New Insights for Oxidative Stress and Diabetes Mellitus

The release of reactive oxygen species (ROS) and the generation of oxidative stress are considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is growing in prevalence and results in significant economic loss. New therapeutic directions that address the detriment...

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Detalles Bibliográficos
Autor principal: Maiese, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443788/
https://www.ncbi.nlm.nih.gov/pubmed/26064426
http://dx.doi.org/10.1155/2015/875961
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author Maiese, Kenneth
author_facet Maiese, Kenneth
author_sort Maiese, Kenneth
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description The release of reactive oxygen species (ROS) and the generation of oxidative stress are considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is growing in prevalence and results in significant economic loss. New therapeutic directions that address the detrimental effects of oxidative stress may be especially warranted to develop effective care for the millions of individuals that currently suffer from DM. The mechanistic target of rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S. cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM since these pathways can address the complex relationship between stem cells, trophic factors, impaired glucose tolerance, programmed cell death pathways of apoptosis and autophagy, tissue remodeling, cellular energy homeostasis, and vascular biology that greatly impact the biology and disease progression of DM. The translation and development of these pathways into viable therapies will require detailed understanding of their proliferative nature to maximize clinical efficacy and limit adverse effects that have the potential to lead to unintended consequences.
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spelling pubmed-44437882015-06-10 New Insights for Oxidative Stress and Diabetes Mellitus Maiese, Kenneth Oxid Med Cell Longev Review Article The release of reactive oxygen species (ROS) and the generation of oxidative stress are considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is growing in prevalence and results in significant economic loss. New therapeutic directions that address the detrimental effects of oxidative stress may be especially warranted to develop effective care for the millions of individuals that currently suffer from DM. The mechanistic target of rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S. cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM since these pathways can address the complex relationship between stem cells, trophic factors, impaired glucose tolerance, programmed cell death pathways of apoptosis and autophagy, tissue remodeling, cellular energy homeostasis, and vascular biology that greatly impact the biology and disease progression of DM. The translation and development of these pathways into viable therapies will require detailed understanding of their proliferative nature to maximize clinical efficacy and limit adverse effects that have the potential to lead to unintended consequences. Hindawi Publishing Corporation 2015 2015-05-12 /pmc/articles/PMC4443788/ /pubmed/26064426 http://dx.doi.org/10.1155/2015/875961 Text en Copyright © 2015 Kenneth Maiese. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Maiese, Kenneth
New Insights for Oxidative Stress and Diabetes Mellitus
title New Insights for Oxidative Stress and Diabetes Mellitus
title_full New Insights for Oxidative Stress and Diabetes Mellitus
title_fullStr New Insights for Oxidative Stress and Diabetes Mellitus
title_full_unstemmed New Insights for Oxidative Stress and Diabetes Mellitus
title_short New Insights for Oxidative Stress and Diabetes Mellitus
title_sort new insights for oxidative stress and diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443788/
https://www.ncbi.nlm.nih.gov/pubmed/26064426
http://dx.doi.org/10.1155/2015/875961
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