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Chromosome mis-segregation and cytokinesis failure in trisomic human cells

Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To test the effects of aneuploidy on chromosome segregation and other mitotic phenotypes we used the colorectal cancer cell line DLD1 (2n = 46) a...

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Detalles Bibliográficos
Autores principales:	Nicholson, Joshua M, Macedo, Joana C, Mattingly, Aaron J, Wangsa, Darawalee, Camps, Jordi, Lima, Vera, Gomes, Ana M, Dória, Sofia, Ried, Thomas, Logarinho, Elsa, Cimini, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443816/ https://www.ncbi.nlm.nih.gov/pubmed/25942454 http://dx.doi.org/10.7554/eLife.05068

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