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Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women
Serum and plasma dehydroepiandrosterone sulfate (DHEAS) concentration has been associated with several health parameters associated with aging including cognitive function, bone mineral density, and muscular strength. However, the effectiveness of salivary DHEA for the prediction of cognitive functi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443930/ https://www.ncbi.nlm.nih.gov/pubmed/26064106 http://dx.doi.org/10.1155/2015/219046 |
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author | Davis, Greggory R. Gallien, Gabrielle J. Moody, Kaitlyn M. LeBlanc, Nina R. Smoak, Peter R. Bellar, David |
author_facet | Davis, Greggory R. Gallien, Gabrielle J. Moody, Kaitlyn M. LeBlanc, Nina R. Smoak, Peter R. Bellar, David |
author_sort | Davis, Greggory R. |
collection | PubMed |
description | Serum and plasma dehydroepiandrosterone sulfate (DHEAS) concentration has been associated with several health parameters associated with aging including cognitive function, bone mineral density, and muscular strength. However, the effectiveness of salivary DHEA for the prediction of cognitive function, bone mineral density, and muscular strength in older adults is currently unknown. Thirty elderly African American females provided early morning salivary samples and DHEA levels were determined using a commercially available immunoassay. Participants completed testing for psychomotor and executive function via Trail Making Tests (TMT) A and B, respectively. Bone ultrasound attenuation (BUA) was used to bone density and an isometric mid-thigh pull (IMTP) was used to determine isometric strength. Age significantly correlated with time on TMT A (r=0.328) and B (r=0.615) but was not related to DHEA, BUA, or IMTP outcomes. Elevated DHEA was associated with longer time to completion for TMT A (χ (2) = 5.14) but not to TMT B. DHEA levels were not associated with BUA or IMTP outcomes. While elevated levels of DHEA were correlated with impaired psychomotor function, salivary DHEA is not associated with executive function, bone mineral density, or isometric strength in elderly African American women. |
format | Online Article Text |
id | pubmed-4443930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44439302015-06-10 Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women Davis, Greggory R. Gallien, Gabrielle J. Moody, Kaitlyn M. LeBlanc, Nina R. Smoak, Peter R. Bellar, David Int J Endocrinol Research Article Serum and plasma dehydroepiandrosterone sulfate (DHEAS) concentration has been associated with several health parameters associated with aging including cognitive function, bone mineral density, and muscular strength. However, the effectiveness of salivary DHEA for the prediction of cognitive function, bone mineral density, and muscular strength in older adults is currently unknown. Thirty elderly African American females provided early morning salivary samples and DHEA levels were determined using a commercially available immunoassay. Participants completed testing for psychomotor and executive function via Trail Making Tests (TMT) A and B, respectively. Bone ultrasound attenuation (BUA) was used to bone density and an isometric mid-thigh pull (IMTP) was used to determine isometric strength. Age significantly correlated with time on TMT A (r=0.328) and B (r=0.615) but was not related to DHEA, BUA, or IMTP outcomes. Elevated DHEA was associated with longer time to completion for TMT A (χ (2) = 5.14) but not to TMT B. DHEA levels were not associated with BUA or IMTP outcomes. While elevated levels of DHEA were correlated with impaired psychomotor function, salivary DHEA is not associated with executive function, bone mineral density, or isometric strength in elderly African American women. Hindawi Publishing Corporation 2015 2015-05-12 /pmc/articles/PMC4443930/ /pubmed/26064106 http://dx.doi.org/10.1155/2015/219046 Text en Copyright © 2015 Greggory R. Davis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Davis, Greggory R. Gallien, Gabrielle J. Moody, Kaitlyn M. LeBlanc, Nina R. Smoak, Peter R. Bellar, David Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title | Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title_full | Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title_fullStr | Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title_full_unstemmed | Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title_short | Cognitive Function and Salivary DHEA Levels in Physically Active Elderly African American Women |
title_sort | cognitive function and salivary dhea levels in physically active elderly african american women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443930/ https://www.ncbi.nlm.nih.gov/pubmed/26064106 http://dx.doi.org/10.1155/2015/219046 |
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