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Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study

BACKGROUND: Persons with diabetes have increased risk of depression, however, studies addressing whether the risk varies by age and type of antidiabetic treatment have yielded conflicting results. The aim of this study was to investigate if the association between diabetes and depression varied by t...

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Autores principales: Berge, Line I., Riise, Trond, Tell, Grethe S., Iversen, Marjolein M., Østbye, Truls, Lund, Anders, Knudsen, Ann Kristin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444007/
https://www.ncbi.nlm.nih.gov/pubmed/26010615
http://dx.doi.org/10.1371/journal.pone.0127161
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author Berge, Line I.
Riise, Trond
Tell, Grethe S.
Iversen, Marjolein M.
Østbye, Truls
Lund, Anders
Knudsen, Ann Kristin
author_facet Berge, Line I.
Riise, Trond
Tell, Grethe S.
Iversen, Marjolein M.
Østbye, Truls
Lund, Anders
Knudsen, Ann Kristin
author_sort Berge, Line I.
collection PubMed
description BACKGROUND: Persons with diabetes have increased risk of depression, however, studies addressing whether the risk varies by age and type of antidiabetic treatment have yielded conflicting results. The aim of this study was to investigate if the association between diabetes and depression varied by type of antidiabetic treatment in a large community based sample of middle-aged (40–47 years) and older adults (70–72 years). METHODS: Data from 21845 participants in the Hordaland Health Study (HUSK) were analyzed in a cross-sectional design. Diabetes was assessed by self-report and classified as un-medicated, treated by oral antidiabetic agents or by insulin. Depression was defined as a score ≥8 on the depression subscale of the Hospital Anxiety and Depression Scale and/or self-reported use of antidepressant agents. Associations between diabetes and depression were estimated using logistic regression. RESULTS: Persons in their forties with diabetes had a doubled prevalence of depression (OR: 1.96 (95% C.I.: 1.35, 2.83)) compared to persons without diabetes, while a lower and non-significant association was found among persons in their seventies. Persons in their forties with orally treated diabetes had about three times higher prevalence of depression (OR: 2.92 (95% C.I.: 1.48, 5.77)) after adjustment for gender, BMI, physical activity, alcohol consumption and education, compared to non-diabetic persons in the same age-group. No association between depression and insulin or un-medicated diabetes was found. CONCLUSIONS: Clinicians should be aware that persons in their forties with orally treated diabetes are at a marked increased risk of depression.
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spelling pubmed-44440072015-06-16 Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study Berge, Line I. Riise, Trond Tell, Grethe S. Iversen, Marjolein M. Østbye, Truls Lund, Anders Knudsen, Ann Kristin PLoS One Research Article BACKGROUND: Persons with diabetes have increased risk of depression, however, studies addressing whether the risk varies by age and type of antidiabetic treatment have yielded conflicting results. The aim of this study was to investigate if the association between diabetes and depression varied by type of antidiabetic treatment in a large community based sample of middle-aged (40–47 years) and older adults (70–72 years). METHODS: Data from 21845 participants in the Hordaland Health Study (HUSK) were analyzed in a cross-sectional design. Diabetes was assessed by self-report and classified as un-medicated, treated by oral antidiabetic agents or by insulin. Depression was defined as a score ≥8 on the depression subscale of the Hospital Anxiety and Depression Scale and/or self-reported use of antidepressant agents. Associations between diabetes and depression were estimated using logistic regression. RESULTS: Persons in their forties with diabetes had a doubled prevalence of depression (OR: 1.96 (95% C.I.: 1.35, 2.83)) compared to persons without diabetes, while a lower and non-significant association was found among persons in their seventies. Persons in their forties with orally treated diabetes had about three times higher prevalence of depression (OR: 2.92 (95% C.I.: 1.48, 5.77)) after adjustment for gender, BMI, physical activity, alcohol consumption and education, compared to non-diabetic persons in the same age-group. No association between depression and insulin or un-medicated diabetes was found. CONCLUSIONS: Clinicians should be aware that persons in their forties with orally treated diabetes are at a marked increased risk of depression. Public Library of Science 2015-05-26 /pmc/articles/PMC4444007/ /pubmed/26010615 http://dx.doi.org/10.1371/journal.pone.0127161 Text en © 2015 Berge et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Berge, Line I.
Riise, Trond
Tell, Grethe S.
Iversen, Marjolein M.
Østbye, Truls
Lund, Anders
Knudsen, Ann Kristin
Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title_full Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title_fullStr Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title_full_unstemmed Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title_short Depression in Persons with Diabetes by Age and Antidiabetic Treatment: A Cross-Sectional Analysis with Data from the Hordaland Health Study
title_sort depression in persons with diabetes by age and antidiabetic treatment: a cross-sectional analysis with data from the hordaland health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444007/
https://www.ncbi.nlm.nih.gov/pubmed/26010615
http://dx.doi.org/10.1371/journal.pone.0127161
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