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Atomic Insight into the Altered O(6)-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer

O(6)-methylguanine-DNA methyltransferase (MGMT) is one of the major DNA repair protein that counteracts the alkalyting agent-induced DNA damage by replacing O(6)-methylguanine (mutagenic lesion) back to guanine, eventually suppressing the mismatch errors and double strand crosslinks. Exonic alterati...

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Detalles Bibliográficos
Autores principales:	Chikan, Naveed Anjum, Bukhari, Shoiab, Shabir, Nadeem, Amin, Asif, Shafi, Sheikh, Qadri, Raies Ahmad, Patel, Trupti Navin Chandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444098/ https://www.ncbi.nlm.nih.gov/pubmed/26011121 http://dx.doi.org/10.1371/journal.pone.0127741

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