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Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study

PURPOSE: To describe trends, patterns, and determinants of prescription drug use during pregnancy and postpartum. METHODS: This is a retrospective, population-based study of all women who gave birth between January 2002 and 31 December 2011 in British Columbia, Canada. Study population consisted of...

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Autores principales: Smolina, Kate, Hanley, Gillian E., Mintzes, Barbara, Oberlander, Tim F., Morgan, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444135/
https://www.ncbi.nlm.nih.gov/pubmed/26011706
http://dx.doi.org/10.1371/journal.pone.0128312
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author Smolina, Kate
Hanley, Gillian E.
Mintzes, Barbara
Oberlander, Tim F.
Morgan, Steve
author_facet Smolina, Kate
Hanley, Gillian E.
Mintzes, Barbara
Oberlander, Tim F.
Morgan, Steve
author_sort Smolina, Kate
collection PubMed
description PURPOSE: To describe trends, patterns, and determinants of prescription drug use during pregnancy and postpartum. METHODS: This is a retrospective, population-based study of all women who gave birth between January 2002 and 31 December 2011 in British Columbia, Canada. Study population consisted of 225,973 women who had 322,219 pregnancies. We examined administrative datasets containing person-specific information on filled prescriptions, hospitalizations, and medical services. Main outcome measures were filled prescriptions during pregnancy and postpartum. We used logistic regressions to examine associations between prescription drug use and maternal characteristics. RESULTS: Approximately two thirds of women filled a prescription during pregnancy, increasing from 60% in 2002 to 66% in 2011. The proportion of pregnant women using medicines in all three trimesters of pregnancy increased from 20% in 2002 to 27% in 2011. Use of four or more different types of prescription drug during at least one trimester increased from 8.4% in 2002 to 11.7% in 2011. Higher BMI, smoking during pregnancy, age under 25, carrying multiples, and being diagnosed with a chronic condition all significantly increased the odds of prescription drug use during pregnancy. CONCLUSIONS: The observed increase in the number of prescriptions and number of different drugs being dispensed suggests a trend in prescribing practices with potentially important implications for mothers, their neonates, and caregivers. Monitoring of prescribing practices and further research into the safety of most commonly prescribed medications is crucial in better understanding risks and benefits to the fetus and the mother.
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spelling pubmed-44441352015-06-16 Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study Smolina, Kate Hanley, Gillian E. Mintzes, Barbara Oberlander, Tim F. Morgan, Steve PLoS One Research Article PURPOSE: To describe trends, patterns, and determinants of prescription drug use during pregnancy and postpartum. METHODS: This is a retrospective, population-based study of all women who gave birth between January 2002 and 31 December 2011 in British Columbia, Canada. Study population consisted of 225,973 women who had 322,219 pregnancies. We examined administrative datasets containing person-specific information on filled prescriptions, hospitalizations, and medical services. Main outcome measures were filled prescriptions during pregnancy and postpartum. We used logistic regressions to examine associations between prescription drug use and maternal characteristics. RESULTS: Approximately two thirds of women filled a prescription during pregnancy, increasing from 60% in 2002 to 66% in 2011. The proportion of pregnant women using medicines in all three trimesters of pregnancy increased from 20% in 2002 to 27% in 2011. Use of four or more different types of prescription drug during at least one trimester increased from 8.4% in 2002 to 11.7% in 2011. Higher BMI, smoking during pregnancy, age under 25, carrying multiples, and being diagnosed with a chronic condition all significantly increased the odds of prescription drug use during pregnancy. CONCLUSIONS: The observed increase in the number of prescriptions and number of different drugs being dispensed suggests a trend in prescribing practices with potentially important implications for mothers, their neonates, and caregivers. Monitoring of prescribing practices and further research into the safety of most commonly prescribed medications is crucial in better understanding risks and benefits to the fetus and the mother. Public Library of Science 2015-05-26 /pmc/articles/PMC4444135/ /pubmed/26011706 http://dx.doi.org/10.1371/journal.pone.0128312 Text en © 2015 Smolina et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Smolina, Kate
Hanley, Gillian E.
Mintzes, Barbara
Oberlander, Tim F.
Morgan, Steve
Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title_full Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title_fullStr Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title_full_unstemmed Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title_short Trends and Determinants of Prescription Drug Use during Pregnancy and Postpartum in British Columbia, 2002–2011: A Population-Based Cohort Study
title_sort trends and determinants of prescription drug use during pregnancy and postpartum in british columbia, 2002–2011: a population-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444135/
https://www.ncbi.nlm.nih.gov/pubmed/26011706
http://dx.doi.org/10.1371/journal.pone.0128312
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