The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma

Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in b...

Descripción completa

Detalles Bibliográficos
Autores principales: Sponaas, Anne M, Moen, Siv H, Liabakk, Nina B, Feyzi, Emadoldin, Holien, Toril, Kvam, Solveig, Grøseth, Lill Anny G, Størdal, Berit, Buene, Glenn, Espevik, Terje, Waage, Anders, Standal, Therese, Sundan, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444152/
https://www.ncbi.nlm.nih.gov/pubmed/26029369
http://dx.doi.org/10.1002/iid3.53
_version_ 1782373093807751168
author Sponaas, Anne M
Moen, Siv H
Liabakk, Nina B
Feyzi, Emadoldin
Holien, Toril
Kvam, Solveig
Grøseth, Lill Anny G
Størdal, Berit
Buene, Glenn
Espevik, Terje
Waage, Anders
Standal, Therese
Sundan, Anders
author_facet Sponaas, Anne M
Moen, Siv H
Liabakk, Nina B
Feyzi, Emadoldin
Holien, Toril
Kvam, Solveig
Grøseth, Lill Anny G
Størdal, Berit
Buene, Glenn
Espevik, Terje
Waage, Anders
Standal, Therese
Sundan, Anders
author_sort Sponaas, Anne M
collection PubMed
description Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX(3)CR(1)(+), CD16(+)CD14(dim) non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10–30% bone marrow PC.
format Online
Article
Text
id pubmed-4444152
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BlackWell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-44441522015-05-29 The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma Sponaas, Anne M Moen, Siv H Liabakk, Nina B Feyzi, Emadoldin Holien, Toril Kvam, Solveig Grøseth, Lill Anny G Størdal, Berit Buene, Glenn Espevik, Terje Waage, Anders Standal, Therese Sundan, Anders Immun Inflamm Dis Original Research Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth and may play a role in the drug response. We therefore characterized monocytes in bone marrow aspirates by flow cytometry. We found that there was significant correlation between the proportion of CX(3)CR(1)(+), CD16(+)CD14(dim) non classical monocytes, and percent plasma cells (PC) in the bone marrow of myeloma patients. The bone marrow monocytes could be stimulated by TLR ligands to produce cytokines which promote myeloma cell growth. The proportion of the non-classical monocytes increased with the tumor load, particularly in patients with tumor loads in the range of 10–30% bone marrow PC. BlackWell Publishing Ltd 2015-06 2015-03-02 /pmc/articles/PMC4444152/ /pubmed/26029369 http://dx.doi.org/10.1002/iid3.53 Text en © 2015 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Sponaas, Anne M
Moen, Siv H
Liabakk, Nina B
Feyzi, Emadoldin
Holien, Toril
Kvam, Solveig
Grøseth, Lill Anny G
Størdal, Berit
Buene, Glenn
Espevik, Terje
Waage, Anders
Standal, Therese
Sundan, Anders
The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title_full The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title_fullStr The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title_full_unstemmed The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title_short The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
title_sort proportion of cd16(+)cd14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444152/
https://www.ncbi.nlm.nih.gov/pubmed/26029369
http://dx.doi.org/10.1002/iid3.53
work_keys_str_mv AT sponaasannem theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT moensivh theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT liabakkninab theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT feyziemadoldin theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT holientoril theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT kvamsolveig theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT grøsethlillannyg theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT størdalberit theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT bueneglenn theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT espevikterje theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT waageanders theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT standaltherese theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT sundananders theproportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT sponaasannem proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT moensivh proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT liabakkninab proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT feyziemadoldin proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT holientoril proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT kvamsolveig proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT grøsethlillannyg proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT størdalberit proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT bueneglenn proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT espevikterje proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT waageanders proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT standaltherese proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma
AT sundananders proportionofcd16cd14dimmonocytesincreaseswithtumorcellloadinbonemarrowofpatientswithmultiplemyeloma

Ejemplares similares