Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways

Lung cancer is by far the leading cause of cancer death. Early diagnosis and prevention remain the best approach to reduce the overall morbidity and mortality. Experimental and clinical evidence have shown that cyclooxygenase-2 (COX-2) derived prostaglandin E(2) (PGE2) contributes to lung tumorigene...

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Detalles Bibliográficos
Autores principales: Chang, Jian, Xue, Min, Yang, Shilin, Yao, Bing, Zhang, Bixiang, Chen, Xiaoping, Pozzi, Ambra, Zhang, Ming-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444260/
https://www.ncbi.nlm.nih.gov/pubmed/26011146
http://dx.doi.org/10.1371/journal.pone.0127030

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