Cargando…

Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon

Huntington’s disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to a variety of functions including transcriptional r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruzo, Albert, Ismailoglu, Ismail, Popowski, Melissa, Haremaki, Tomomi, Croft, Gist F., Deglincerti, Alessia, Brivanlou, Ali H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444280/ https://www.ncbi.nlm.nih.gov/pubmed/26010866 http://dx.doi.org/10.1371/journal.pone.0127687

Ejemplares similares

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects
por: Galgoczi, Szilvia, et al.
Publicado: (2021)

The Brain in Hominid Evolution
por: Zielonka, Jason S.
Publicado: (1972)

Hominids Lose Control
Publicado: (2005)

Hominid sexual nature
por: Mogielnicki, Christopher, et al.
Publicado: (2020)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
por: Chiki, Anass, et al.
Publicado: (2020)

Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1
por: Southwell, Amber L., et al.
Publicado: (2011)

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression
por: Chen, Xu-Qiao, et al.
Publicado: (2021)

Hominid culture in primate perspective /
Publicado: (1994)

Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice
por: Zhao, Xianxian, et al.
Publicado: (2022)

Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer’s Disease and Inhibitors of Amyloid Formation
por: Liu, Qing-Rong, et al.
Publicado: (2023)

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Hominid Evolution: Past, Present and Future
por: Louis, Elan D.
Publicado: (1986)

Understanding the Degradation of Hominid Gene Control
por: Keightley, Peter D, et al.
Publicado: (2006)

A pathogenic proteolysis–resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function
por: Kim, Hyeongju, et al.
Publicado: (2022)

Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments
por: Butler, David C., et al.
Publicado: (2011)

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
por: Yang, Huiming, et al.
Publicado: (2020)

Selective Constraint on Noncoding Regions of Hominid Genomes
por: Bush, Eliot C, et al.
Publicado: (2005)

A New Malaria Agent in African Hominids
por: Ollomo, Benjamin, et al.
Publicado: (2009)

Explaining the Imperfection of the Molecular Clock of Hominid Mitochondria
por: Loogväli, Eva-Liis, et al.
Publicado: (2009)

Chimps, Humans, and the Hominid Struggle against Viruses
por: Roberts, Roland G.
Publicado: (2015)

The Complexity and Phylogenetic Continuity of Laughter and Smiles in Hominids
por: Davila-Ross, Marina, et al.
Publicado: (2021)

Integrating networks and comparative genomics reveals retroelement proliferation dynamics in hominid genomes
por: Levy, Orr, et al.
Publicado: (2017)

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences
por: Lakhani, Vinal V., et al.
Publicado: (2010)

Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1
por: Sahoo, Bankanidhi, et al.
Publicado: (2014)

Huntingtin CAG-expansion mutation results in a dominant negative effect
por: Laundos, Tiago L., et al.
Publicado: (2023)

Insights into hominid evolution from the gorilla genome sequence
por: Scally, Aylwyn, et al.
Publicado: (2012)

Widespread Genomic Signatures of Natural Selection in Hominid Evolution
por: McVicker, Graham, et al.
Publicado: (2009)

New evidence for early presence of hominids in North China
por: Ao, Hong, et al.
Publicado: (2013)

Hominid butchers and biting crocodiles in the African Plio–Pleistocene
por: Sahle, Yonatan, et al.
Publicado: (2017)

The Evolutionary Radiation of Hominids: a Phylogenetic Comparative Study
por: Rocatti, Guido, et al.
Publicado: (2019)

The evolution and changing ecology of the African hominid oral microbiome
por: Fellows Yates, James A., et al.
Publicado: (2021)

Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models
por: Metzger, Jakob J., et al.
Publicado: (2022)

Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms
por: Gruber, Andreas J., et al.
Publicado: (2018)

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane
por: Monsellier, Elodie, et al.
Publicado: (2016)

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation
por: Peskett, Thomas R., et al.
Publicado: (2018)

Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
por: Keightley, Peter D, et al.
Publicado: (2005)

Evolutionary Relationships of Wild Hominids Recapitulated by Gut Microbial Communities
por: Ochman, Howard, et al.
Publicado: (2010)

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1
por: Harding, Rachel J., et al.
Publicado: (2021)

Polyglutamine disruption of the huntingtin exon1 N-terminus triggers a complex aggregation mechanism
por: Thakur, Ashwani K., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_h90c5kddnp8riimj4j2hjej1ip