Cargando…
The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study
The study aims to investigate the effect of repeated infusions of recombinant erythropoietin (EPO) on plasma brain derived neurotrophic factor (BDNF) levels in patients with affective disorders. In total, 83 patients were recruited: 40 currently depressed patients with treatment-resistant depression...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444304/ https://www.ncbi.nlm.nih.gov/pubmed/26011424 http://dx.doi.org/10.1371/journal.pone.0127629 |
_version_ | 1782373127546732544 |
---|---|
author | Vinberg, Maj Miskowiak, Kamilla Hoejman, Pernille Pedersen, Maria Kessing, Lars Vedel |
author_facet | Vinberg, Maj Miskowiak, Kamilla Hoejman, Pernille Pedersen, Maria Kessing, Lars Vedel |
author_sort | Vinberg, Maj |
collection | PubMed |
description | The study aims to investigate the effect of repeated infusions of recombinant erythropoietin (EPO) on plasma brain derived neurotrophic factor (BDNF) levels in patients with affective disorders. In total, 83 patients were recruited: 40 currently depressed patients with treatment-resistant depression (TRD) (Hamilton Depression Rating Scale-17 items (HDRS-17) score >17) (study 1) and 43 patients with bipolar disorder (BD) in partial remission (HDRS-17 and Young Mania Rating Scale (YMRS) ≤ 14) (study 2). In both studies, patients were randomised to receive eight weekly EPO (Eprex; 40,000 IU) or saline (0.9% NaCl) infusions in a double-blind, placebo-controlled, parallel—group design. Plasma BDNF levels were measured at baseline and at weeks 5, 9 and at follow up, week 14. In contrast with our hypothesis, EPO down regulated plasma BDNF levels in patients with TRD (mean reduction at week 9 (95% CI): EPO 10.94 ng/l (4.51-21.41 ng/l); mean increase at week 9: Saline 0.52 ng/l, p=0.04 (-5.88-4.48 ng/l) p=0.04, partial ŋ(2)=0.12). No significant effects were found on BDNF levels in partially remitted patients with BD (p=0.35). The present effects of EPO on BDNF levels in patients with TRD point to a role of neurotrophic factors in the potential effects of EPO seen in TRD and BD. The neurobiological mechanisms underlying these effects and the interaction between EPO and peripheral levels on BDNF need to be further elucidated in human studies including a broad range of biomarkers. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00916552. |
format | Online Article Text |
id | pubmed-4444304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44443042015-06-16 The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study Vinberg, Maj Miskowiak, Kamilla Hoejman, Pernille Pedersen, Maria Kessing, Lars Vedel PLoS One Research Article The study aims to investigate the effect of repeated infusions of recombinant erythropoietin (EPO) on plasma brain derived neurotrophic factor (BDNF) levels in patients with affective disorders. In total, 83 patients were recruited: 40 currently depressed patients with treatment-resistant depression (TRD) (Hamilton Depression Rating Scale-17 items (HDRS-17) score >17) (study 1) and 43 patients with bipolar disorder (BD) in partial remission (HDRS-17 and Young Mania Rating Scale (YMRS) ≤ 14) (study 2). In both studies, patients were randomised to receive eight weekly EPO (Eprex; 40,000 IU) or saline (0.9% NaCl) infusions in a double-blind, placebo-controlled, parallel—group design. Plasma BDNF levels were measured at baseline and at weeks 5, 9 and at follow up, week 14. In contrast with our hypothesis, EPO down regulated plasma BDNF levels in patients with TRD (mean reduction at week 9 (95% CI): EPO 10.94 ng/l (4.51-21.41 ng/l); mean increase at week 9: Saline 0.52 ng/l, p=0.04 (-5.88-4.48 ng/l) p=0.04, partial ŋ(2)=0.12). No significant effects were found on BDNF levels in partially remitted patients with BD (p=0.35). The present effects of EPO on BDNF levels in patients with TRD point to a role of neurotrophic factors in the potential effects of EPO seen in TRD and BD. The neurobiological mechanisms underlying these effects and the interaction between EPO and peripheral levels on BDNF need to be further elucidated in human studies including a broad range of biomarkers. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00916552. Public Library of Science 2015-05-26 /pmc/articles/PMC4444304/ /pubmed/26011424 http://dx.doi.org/10.1371/journal.pone.0127629 Text en © 2015 Vinberg et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Vinberg, Maj Miskowiak, Kamilla Hoejman, Pernille Pedersen, Maria Kessing, Lars Vedel The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title | The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title_full | The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title_fullStr | The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title_full_unstemmed | The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title_short | The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study |
title_sort | effect of recombinant erythropoietin on plasma brain derived neurotrophic factor levels in patients with affective disorders: a randomised controlled study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444304/ https://www.ncbi.nlm.nih.gov/pubmed/26011424 http://dx.doi.org/10.1371/journal.pone.0127629 |
work_keys_str_mv | AT vinbergmaj theeffectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT miskowiakkamilla theeffectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT hoejmanpernille theeffectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT pedersenmaria theeffectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT kessinglarsvedel theeffectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT vinbergmaj effectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT miskowiakkamilla effectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT hoejmanpernille effectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT pedersenmaria effectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy AT kessinglarsvedel effectofrecombinanterythropoietinonplasmabrainderivedneurotrophicfactorlevelsinpatientswithaffectivedisordersarandomisedcontrolledstudy |