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Fate of the Molar Dental Lamina in the Monophyodont Mouse
The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444311/ https://www.ncbi.nlm.nih.gov/pubmed/26010446 http://dx.doi.org/10.1371/journal.pone.0127543 |
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author | Dosedělová, Hana Dumková, Jana Lesot, Hervé Glocová, Kristýna Kunová, Michaela Tucker, Abigail S. Veselá, Iva Krejčí, Pavel Tichý, František Hampl, Aleš Buchtová, Marcela |
author_facet | Dosedělová, Hana Dumková, Jana Lesot, Hervé Glocová, Kristýna Kunová, Michaela Tucker, Abigail S. Veselá, Iva Krejčí, Pavel Tichý, František Hampl, Aleš Buchtová, Marcela |
author_sort | Dosedělová, Hana |
collection | PubMed |
description | The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity. |
format | Online Article Text |
id | pubmed-4444311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44443112015-06-16 Fate of the Molar Dental Lamina in the Monophyodont Mouse Dosedělová, Hana Dumková, Jana Lesot, Hervé Glocová, Kristýna Kunová, Michaela Tucker, Abigail S. Veselá, Iva Krejčí, Pavel Tichý, František Hampl, Aleš Buchtová, Marcela PLoS One Research Article The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity. Public Library of Science 2015-05-26 /pmc/articles/PMC4444311/ /pubmed/26010446 http://dx.doi.org/10.1371/journal.pone.0127543 Text en © 2015 Dosedělová et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Dosedělová, Hana Dumková, Jana Lesot, Hervé Glocová, Kristýna Kunová, Michaela Tucker, Abigail S. Veselá, Iva Krejčí, Pavel Tichý, František Hampl, Aleš Buchtová, Marcela Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title | Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title_full | Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title_fullStr | Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title_full_unstemmed | Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title_short | Fate of the Molar Dental Lamina in the Monophyodont Mouse |
title_sort | fate of the molar dental lamina in the monophyodont mouse |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444311/ https://www.ncbi.nlm.nih.gov/pubmed/26010446 http://dx.doi.org/10.1371/journal.pone.0127543 |
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