Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial t...

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Detalles Bibliográficos
Autores principales: Cunniff, Brian, Newick, Kheng, Nelson, Kimberly J., Wozniak, Alexandra N., Beuschel, Stacie, Leavitt, Bruce, Bhave, Anant, Butnor, Kelly, Koenig, Andreas, Chouchani, Edward T., James, Andrew M., Haynes, Alexina C., Lowther, W. Todd, Murphy, Michael P., Shukla, Arti, Heintz, Nicholas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444329/
https://www.ncbi.nlm.nih.gov/pubmed/26011724
http://dx.doi.org/10.1371/journal.pone.0127310

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