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Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural prot...

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Detalles Bibliográficos
Autores principales: Narayanan, Krishna, Ramirez, Sydney I., Lokugamage, Kumari G., Makino, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444399/
https://www.ncbi.nlm.nih.gov/pubmed/25432065
http://dx.doi.org/10.1016/j.virusres.2014.11.019
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author Narayanan, Krishna
Ramirez, Sydney I.
Lokugamage, Kumari G.
Makino, Shinji
author_facet Narayanan, Krishna
Ramirez, Sydney I.
Lokugamage, Kumari G.
Makino, Shinji
author_sort Narayanan, Krishna
collection PubMed
description The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection.
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spelling pubmed-44443992016-04-16 Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression Narayanan, Krishna Ramirez, Sydney I. Lokugamage, Kumari G. Makino, Shinji Virus Res Article The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection. Elsevier B.V. 2015-04-16 2014-11-26 /pmc/articles/PMC4444399/ /pubmed/25432065 http://dx.doi.org/10.1016/j.virusres.2014.11.019 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Narayanan, Krishna
Ramirez, Sydney I.
Lokugamage, Kumari G.
Makino, Shinji
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title_full Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title_fullStr Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title_full_unstemmed Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title_short Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression
title_sort coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444399/
https://www.ncbi.nlm.nih.gov/pubmed/25432065
http://dx.doi.org/10.1016/j.virusres.2014.11.019
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