Cargando…

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

In gene therapy for congenital disorders, treatments during neonate and infant stages are promising. Replication-incompetent adenovirus (Ad) vectors have been used in gene therapy studies of genetic disorders; however, the transduction properties of Ad vectors in neonates and infants have not been f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iizuka, Shunsuke, Sakurai, Fuminori, Shimizu, Kahori, Ohashi, Kazuo, Nakamura, Shin-ichiro, Tachibana, Masashi, Mizuguchi, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444570/ https://www.ncbi.nlm.nih.gov/pubmed/26075257 http://dx.doi.org/10.1155/2015/685374

Ejemplares similares

Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes
por: Iizuka, Shunsuke, et al.
Publicado: (2017)

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome
por: Shimizu, Kahori, et al.
Publicado: (2014)

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration
por: Tomita, Kyoko, et al.
Publicado: (2018)

Adenovirus vector-based vaccine for infectious diseases
por: Sakurai, Fuminori, et al.
Publicado: (2022)

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses
por: Machitani, Mitsuhiro, et al.
Publicado: (2011)

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis
por: Shimizu, Kahori, et al.
Publicado: (2017)

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA
por: Machitani, Mitsuhiro, et al.
Publicado: (2016)

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination
por: Hemmi, Masahisa, et al.
Publicado: (2017)

The Early Activation of CD8(+) T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector
por: Hemmi, Masahisa, et al.
Publicado: (2014)

NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector
por: Machitani, M., et al.
Publicado: (2016)

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB
por: Machitani, Mitsuhiro, et al.
Publicado: (2017)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35
por: Ono, Ryosuke, et al.
Publicado: (2021)

Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B
por: Okamoto, Ryota, et al.
Publicado: (2018)

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus
por: Ono, Ryosuke, et al.
Publicado: (2022)

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
por: Nakamori, Daiki, et al.
Publicado: (2017)

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients
por: Ikemoto, Sena, et al.
Publicado: (2023)

Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells
por: Katayama, Yuki, et al.
Publicado: (2015)

Regulation of synovial cell function by adenovirus vector-mediated gene transduction
por: Tanaka, S, et al.
Publicado: (2003)

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine
por: Ozawa, Tatsuya, et al.
Publicado: (2015)

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus
por: Sakurai, Fuminori, et al.
Publicado: (2016)

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA
por: Machitani, Mitsuhiro, et al.
Publicado: (2017)

Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes
por: Takayama, Kazuo, et al.
Publicado: (2013)

Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction
por: Takayama, Kazuo, et al.
Publicado: (2011)

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
por: Sakurai, Fuminori, et al.
Publicado: (2017)

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system
por: Takayama, Kazuo, et al.
Publicado: (2017)

A trial of somatic gene targeting in vivo with an adenovirus vector
por: Ino, Asami, et al.
Publicado: (2005)

Efficient Transduction of Primary Vascular Cells by the Rare Adenovirus Serotype 49 Vector
por: Dakin, Rachel S., et al.
Publicado: (2015)

Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase‐positive cells
por: Takakura, Masahiro, et al.
Publicado: (2017)

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism
por: Zhou, Haoyang, et al.
Publicado: (2022)

The infectivity of progeny adenovirus in the presence of neutralizing antibody
por: Hirai, Takamasa, et al.
Publicado: (2021)

Adenovirus vector-mediated assay system for hepatitis C virus replication
por: Yoshida, Takeshi, et al.
Publicado: (2011)

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2
por: Sakai, Eiko, et al.
Publicado: (2017)

Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice
por: Shimizu, Kahori, et al.
Publicado: (2022)

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells
por: Imagawa, Kazuo, et al.
Publicado: (2017)

Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors
por: de Vrij, Jeroen, et al.
Publicado: (2011)

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin
por: Watanabe, Hitoshi, et al.
Publicado: (2014)

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
por: Negoro, Ryosuke, et al.
Publicado: (2018)

FGF signal is not required for hepatoblast differentiation of human iPS cells
por: Toba, Yukiko, et al.
Publicado: (2019)

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors
por: Hotani, Takuma, et al.
Publicado: (2018)

Cytokine Responses to Adenovirus and Adenovirus Vectors
por: Atasheva, Svetlana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c0gc2j7cu3kc1ea95k6cbcqmlp