Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the fu...

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Detalles Bibliográficos
Autores principales: Portugal, Silvia, Tipton, Christopher M, Sohn, Haewon, Kone, Younoussou, Wang, Jing, Li, Shanping, Skinner, Jeff, Virtaneva, Kimmo, Sturdevant, Daniel E, Porcella, Stephen F, Doumbo, Ogobara K, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Sanz, Inaki, Pierce, Susan K, Crompton, Peter D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444601/
https://www.ncbi.nlm.nih.gov/pubmed/25955968
http://dx.doi.org/10.7554/eLife.07218

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