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Fabrication of Fe(3)O(4)@mSiO(2) Core-Shell Composite Nanoparticles for Drug Delivery Applications
We report the synthesis of Fe(3)O(4)@mSiO(2) nanostructures of different meso-silica (mSiO(2)) shell thickness, their biocompatibility and behaviors for loading and release of a model drug ibuprofen. The composite nanostructures have superparamagnetic magnetite cores of 208 nm average size and meso-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444644/ https://www.ncbi.nlm.nih.gov/pubmed/26034415 http://dx.doi.org/10.1186/s11671-015-0920-5 |
Sumario: | We report the synthesis of Fe(3)O(4)@mSiO(2) nanostructures of different meso-silica (mSiO(2)) shell thickness, their biocompatibility and behaviors for loading and release of a model drug ibuprofen. The composite nanostructures have superparamagnetic magnetite cores of 208 nm average size and meso-silica shells of 15 to 40 nm thickness. A modified Stöber method was used to grow the meso-silica shells over the hydrothermally grown monodispersed magnetite particles. The composite nanoparticles show very promising drug holding and releasing behaviors, which depend on the thickness of meso-silica shell. The biocompatibility of the meso-silica-coated and uncoated magnetite nanoparticles was tested through cytotoxicity assay on breast cancer (MCF-7), ovarian cancer (SKOV3), normal human lung fibroblasts MRC-5, and IMR-90 cells. The high drug holding capacity and reasonable biocompatibility of the nanostructures make them ideal agents for targeted drug delivery applications in human body. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-015-0920-5) contains supplementary material, which is available to authorized users. |
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