Theoretical and simulation studies on voltage-gated sodium channels

Voltage-gated sodium (Na(v)) channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Na(v) channels in recent years greatly promote the mechanistic investigation of these prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yang, Gong, Haipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444806/
https://www.ncbi.nlm.nih.gov/pubmed/25894089
http://dx.doi.org/10.1007/s13238-015-0152-6
_version_ 1782373191780401152
author Li, Yang
Gong, Haipeng
author_facet Li, Yang
Gong, Haipeng
author_sort Li, Yang
collection PubMed
description Voltage-gated sodium (Na(v)) channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Na(v) channels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the progress in computational studies, especially the simulation studies, on these proteins in the past years.
format Online
Article
Text
id pubmed-4444806
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Higher Education Press
record_format MEDLINE/PubMed
spelling pubmed-44448062015-05-29 Theoretical and simulation studies on voltage-gated sodium channels Li, Yang Gong, Haipeng Protein Cell Review Voltage-gated sodium (Na(v)) channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Na(v) channels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the progress in computational studies, especially the simulation studies, on these proteins in the past years. Higher Education Press 2015-04-17 2015-06 /pmc/articles/PMC4444806/ /pubmed/25894089 http://dx.doi.org/10.1007/s13238-015-0152-6 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Li, Yang
Gong, Haipeng
Theoretical and simulation studies on voltage-gated sodium channels
title Theoretical and simulation studies on voltage-gated sodium channels
title_full Theoretical and simulation studies on voltage-gated sodium channels
title_fullStr Theoretical and simulation studies on voltage-gated sodium channels
title_full_unstemmed Theoretical and simulation studies on voltage-gated sodium channels
title_short Theoretical and simulation studies on voltage-gated sodium channels
title_sort theoretical and simulation studies on voltage-gated sodium channels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444806/
https://www.ncbi.nlm.nih.gov/pubmed/25894089
http://dx.doi.org/10.1007/s13238-015-0152-6
work_keys_str_mv AT liyang theoreticalandsimulationstudiesonvoltagegatedsodiumchannels
AT gonghaipeng theoreticalandsimulationstudiesonvoltagegatedsodiumchannels

Ejemplares similares