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Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats

Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system. BmK I, a site-3 sodium channel-specific toxin from scorpion Buthus martensi Karsch, induces pain behaviors in rats. However, the subtypes of VGSCs targeted by...

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Detalles Bibliográficos
Autores principales:	Ye, Pin, Jiao, Yunlu, Li, Zhenwei, Hua, Liming, Fu, Jin, Jiang, Feng, Liu, Tong, Ji, Yonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444811/ https://www.ncbi.nlm.nih.gov/pubmed/25903152 http://dx.doi.org/10.1007/s13238-015-0154-4

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