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Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles

Mitotic spindle is the main subcellular structure that accomplishes the chromosome segregation between daughter cells during cell division. However, how mitotic spindles sense and control their size, position and movement inside the cell still remains unclear. In this paper, we focus on the size eff...

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Detalles Bibliográficos
Autor principal: Jiang, Hongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444851/
https://www.ncbi.nlm.nih.gov/pubmed/26015263
http://dx.doi.org/10.1038/srep10504
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author Jiang, Hongyuan
author_facet Jiang, Hongyuan
author_sort Jiang, Hongyuan
collection PubMed
description Mitotic spindle is the main subcellular structure that accomplishes the chromosome segregation between daughter cells during cell division. However, how mitotic spindles sense and control their size, position and movement inside the cell still remains unclear. In this paper, we focus on the size effects of mitotic spindles, i.e., how cell size controls various interesting phenomena in the metaphase, such as oscillation, positioning and size limit of mitotic spindles. We systematically studied the frequency doubling phenomenon during chromosome oscillation and found that cell size can regulate the period and amplitude of chromosome oscillation. We found that the relaxation time of the positioning process increases exponentially with cell size. We also showed that the stabler microtubule-kinetochore attachments alone can directly lead to an upper limit of spindle size. Our work not only explains the existing experimental observations, but also provides some interesting predictions that can be verified or rejected by further experiments.
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spelling pubmed-44448512015-06-01 Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles Jiang, Hongyuan Sci Rep Article Mitotic spindle is the main subcellular structure that accomplishes the chromosome segregation between daughter cells during cell division. However, how mitotic spindles sense and control their size, position and movement inside the cell still remains unclear. In this paper, we focus on the size effects of mitotic spindles, i.e., how cell size controls various interesting phenomena in the metaphase, such as oscillation, positioning and size limit of mitotic spindles. We systematically studied the frequency doubling phenomenon during chromosome oscillation and found that cell size can regulate the period and amplitude of chromosome oscillation. We found that the relaxation time of the positioning process increases exponentially with cell size. We also showed that the stabler microtubule-kinetochore attachments alone can directly lead to an upper limit of spindle size. Our work not only explains the existing experimental observations, but also provides some interesting predictions that can be verified or rejected by further experiments. Nature Publishing Group 2015-05-27 /pmc/articles/PMC4444851/ /pubmed/26015263 http://dx.doi.org/10.1038/srep10504 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Jiang, Hongyuan
Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title_full Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title_fullStr Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title_full_unstemmed Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title_short Cell Size Modulates Oscillation, Positioning and Length of Mitotic Spindles
title_sort cell size modulates oscillation, positioning and length of mitotic spindles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444851/
https://www.ncbi.nlm.nih.gov/pubmed/26015263
http://dx.doi.org/10.1038/srep10504
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