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Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction

The prometastatic calcium-binding protein, S100A4, is expressed in endothelial cells, and its downregulation markedly suppresses tumor angiogenesis in a xenograft cancer model. Given that endothelial S100A4 can be a molecular target for inhibiting tumor angiogenesis, we addressed here whether synthe...

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Detalles Bibliográficos
Autores principales:	Ochiya, Takahiro, Takenaga, Keizo, Asagiri, Masataka, Nakano, Kazumi, Satoh, Hitoshi, Watanabe, Toshiki, Imajoh-Ohmi, Shinobu, Endo, Hideya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445002/ https://www.ncbi.nlm.nih.gov/pubmed/26029719 http://dx.doi.org/10.1038/mtm.2015.8

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