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Depsipeptide Intermediates Interrogate Proposed Biosynthesis of Cereulide, the Emetic Toxin of Bacillus cereus

Cereulide and isocereulides A-G are biosynthesized as emetic toxins by Bacillus cereus via a non-ribosomal peptide synthetase (NRPS) called Ces. Although a thiotemplate mechanisms involving cyclo-trimerization of ready-made D-O-Leu-D-Ala-L-O-Val-L-Val via a thioesterase (TE) domain is proposed for c...

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Detalles Bibliográficos
Autores principales:	Marxen, Sandra, Stark, Timo D., Rütschle, Andrea, Lücking, Genia, Frenzel, Elrike, Scherer, Siegfried, Ehling-Schulz, Monika, Hofmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445039/ https://www.ncbi.nlm.nih.gov/pubmed/26013201 http://dx.doi.org/10.1038/srep10637

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