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Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages

OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age ran...

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Autores principales: Gupta, Shreya, Deoskar, Anuradha, Gupta, Puneet, Jain, Sandhya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dental Press International 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445228/
https://www.ncbi.nlm.nih.gov/pubmed/25992990
http://dx.doi.org/10.1590/2176-9451.20.2.068-075.oar
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author Gupta, Shreya
Deoskar, Anuradha
Gupta, Puneet
Jain, Sandhya
author_facet Gupta, Shreya
Deoskar, Anuradha
Gupta, Puneet
Jain, Sandhya
author_sort Gupta, Shreya
collection PubMed
description OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and cervical staging data of 30 female subjects were included and taken from records of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test. Bonferroni correction was carried out and alpha value was set at 0.003. RESULTS: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4 in males. Differences between males and females were observed in mean values of IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed in CS4 followed by CS5 and third highest in CS3; whereas in females the highest mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5. Trends of IGF-1 in relation to the cervical stages also differed between males and females. The greatest mean serum IGF-1 value for both sexes was comparable, for females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). CONCLUSIONS: Males and females showed differences in IGF-1 trends and levels at different cervical stages.
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spelling pubmed-44452282015-05-28 Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages Gupta, Shreya Deoskar, Anuradha Gupta, Puneet Jain, Sandhya Dental Press J Orthod Articles OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and cervical staging data of 30 female subjects were included and taken from records of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test. Bonferroni correction was carried out and alpha value was set at 0.003. RESULTS: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4 in males. Differences between males and females were observed in mean values of IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed in CS4 followed by CS5 and third highest in CS3; whereas in females the highest mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5. Trends of IGF-1 in relation to the cervical stages also differed between males and females. The greatest mean serum IGF-1 value for both sexes was comparable, for females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). CONCLUSIONS: Males and females showed differences in IGF-1 trends and levels at different cervical stages. Dental Press International 2015 /pmc/articles/PMC4445228/ /pubmed/25992990 http://dx.doi.org/10.1590/2176-9451.20.2.068-075.oar Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Gupta, Shreya
Deoskar, Anuradha
Gupta, Puneet
Jain, Sandhya
Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title_full Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title_fullStr Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title_full_unstemmed Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title_short Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
title_sort serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445228/
https://www.ncbi.nlm.nih.gov/pubmed/25992990
http://dx.doi.org/10.1590/2176-9451.20.2.068-075.oar
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