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Application of quantitative proteomics to the integrated analysis of the ubiquitylated and global proteomes of xenograft tumor tissues

BACKGROUND: Post-translational modification by ubiquitin is a fundamental regulatory mechanism that is implicated in many cellular processes including the cell cycle, apoptosis, cell adhesion, angiogenesis, and tumor growth. The low stoichiometry of ubiquitylation presents an analytical challenge fo...

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Detalles Bibliográficos
Autores principales: Thomas, Stefani N, Zhang, Hui, Cotter, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445283/
https://www.ncbi.nlm.nih.gov/pubmed/26019700
http://dx.doi.org/10.1186/s12014-015-9086-5