Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions

Unequivocal demonstration of the therapeutic utility of γ-retroviral vectors for gene therapy applications targeting the hematopoietic system was accompanied by instances of insertional mutagenesis. These events stimulated the ongoing development of putatively safer integrating vector systems and an...

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Detalles Bibliográficos
Autores principales: Hallwirth, Claus V, Garg, Gagan, Peters, Timothy J, Kramer, Belinda A, Malani, Nirav V, Hyman, Jessica, Ruan, Xiaoan, Ginn, Samantha L, Hetherington, Nicola A, Veeravalli, Lavanya, Shahab, Atif, Ranganathan, Shoba, Wei, Chia-Lin, Liddle, Christopher, Thrasher, Adrian J, Bushman, Frederic D, Buckley, Michael J, Alexander, Ian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445430/
https://www.ncbi.nlm.nih.gov/pubmed/26029726
http://dx.doi.org/10.1038/mtm.2015.15

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