Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management

Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preserva...

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Detalles Bibliográficos
Autores principales: Marzuka, Alexander G., Book, Samuel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445438/
https://www.ncbi.nlm.nih.gov/pubmed/26029015
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author Marzuka, Alexander G.
Book, Samuel E.
author_facet Marzuka, Alexander G.
Book, Samuel E.
author_sort Marzuka, Alexander G.
collection PubMed
description Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease. The pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management of BCC will be discussed in this review.
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spelling pubmed-44454382015-06-01 Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management Marzuka, Alexander G. Book, Samuel E. Yale J Biol Med Review Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease. The pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management of BCC will be discussed in this review. YJBM 2015-06-01 /pmc/articles/PMC4445438/ /pubmed/26029015 Text en Copyright ©2015, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Review
Marzuka, Alexander G.
Book, Samuel E.
Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title_full Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title_fullStr Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title_full_unstemmed Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title_short Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management
title_sort basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445438/
https://www.ncbi.nlm.nih.gov/pubmed/26029015
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