Cargando…

Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways

BACKGROUND: Parkinson’s disease is the second most common neurodegenerative disorders after Alzheimer’s disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. Neuronal apoptosis and neuroinflammation are thought to be the key contributors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yun-Lian, Tsay, Huey-Jen, Lai, Tzu-Hsuan, Tzeng, Tsai-Teng, Shiao, Young-Ji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445499/ https://www.ncbi.nlm.nih.gov/pubmed/26018660 http://dx.doi.org/10.1186/s12929-015-0146-y

Ejemplares similares

Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid
por: Tzeng, Tsai-Teng, et al.
Publicado: (2013)

Amyloid β peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype
por: Tsay, Huey-Jen, et al.
Publicado: (2013)

N-Phenylpyridine-2-carbamide
por: Zhuang, Yu-Guo, et al.
Publicado: (2008)

Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein
por: Mori, Mattia, et al.
Publicado: (2020)

The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway
por: Lin, Yun-Lian, et al.
Publicado: (2012)

Antiviral Effects of Novel 2-Benzoxyl-Phenylpyridine Derivatives
por: Wei, Yanhong, et al.
Publicado: (2020)

Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode
por: Chung, Tse-Yu, et al.
Publicado: (2017)

Magnesium Lithospermate B Attenuates High-Fat Diet-Induced Muscle Atrophy in C57BL/6J Mice
por: Cheng, Tsun-Li, et al.
Publicado: (2021)

The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies in APP/PS1 Transgenic Mice
por: Tzeng, Tsai-Teng, et al.
Publicado: (2018)

Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein
por: Wang, Chung-Jen, et al.
Publicado: (2013)

Dichloridobis(2-phenylpyridine-κN)zinc(II)
por: Dharmalingam, Sivanesan, et al.
Publicado: (2012)

Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways
por: Fouad, Ibram Amin, et al.
Publicado: (2018)

The Effect of Lithospermic Acid, an Antioxidant, on Development of Diabetic Retinopathy in Spontaneously Obese Diabetic Rats
por: Jin, Cheng Ji, et al.
Publicado: (2014)

Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
por: Lim, Eunyoung, et al.
Publicado: (2011)

Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice
por: Shie, Feng-Shiun, et al.
Publicado: (2015)

trans-Dichloridobis(4-phenylpyridine-κN)palladium(II)
por: Ha, Kwang
Publicado: (2011)

trans-Diiodidobis(2-phenylpyridine-κN)palladium(II)
por: Ha, Kwang
Publicado: (2012)

cis-Dichloridobis(2-phenylpyridine-κN)platinum(II)
por: Yoshinari, Nobuto, et al.
Publicado: (2010)

cis-Dibromidobis(2-phenylpyridine-κN)platinum(II)
por: Ha, Kwang
Publicado: (2012)

Synthesis of Novel Pyrazole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

2,6-Bis(4-methoxyphenyl)-4-phenylpyridine
por: Dong, Xiaoning
Publicado: (2009)

Copper-catalyzed C–H acyloxylation of 2-phenylpyridine using oxygen as the oxidant
por: Wang, Feifan, et al.
Publicado: (2018)

Catalytic Activity of New Oxovanadium(IV) Microclusters with 2-Phenylpyridine in Olefin Oligomerization
por: Gawdzik, Barbara, et al.
Publicado: (2021)

Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

Synthesis of Novel α-Trifluoroanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

Magnesium Lithospermate B Protects against Lipopolysaccharide-Induced Bone Loss by Inhibiting RANKL/RANK Pathway
por: Wang, Jihai, et al.
Publicado: (2018)

Magnesium Lithospermate B Downregulates the Levels of Blood Pressure, Inflammation, and Oxidative Stress in Pregnant Rats with Hypertension
por: Xu, Kaixiang, et al.
Publicado: (2020)

GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling
por: Chang, Ching-Chi, et al.
Publicado: (2018)

A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus
por: Buchanan, Jessica B, et al.
Publicado: (2010)

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism
por: Alasmari, Fawaz, et al.
Publicado: (2018)

Dimethyl 2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate
por: Gohain, Mukut, et al.
Publicado: (2011)

2-Amino-6-(naphthalen-1-yl)-4-phenylpyridine-3-carbonitrile
por: Mao, Wei, et al.
Publicado: (2011)

Hybridization vs. Bond Stretching Isomerism in Ru(II) Cyclometalated Complexes of 2-Phenylpyridine
por: Molina, Bertha, et al.
Publicado: (2011)

Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction
por: Shen, Daoqi, et al.
Publicado: (2022)

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease
por: Shal, Bushra, et al.
Publicado: (2018)

4‐phenylpyridine suppresses UVB‐induced skin inflammation by targeting c‐Src in vitro and in vivo
por: Kim, Ju Gyeong, et al.
Publicado: (2022)

Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-βRI/Smad Signaling
por: Luo, Xin, et al.
Publicado: (2021)

Cysteine-rich domain of scavenger receptor Al modulates the efficacy of surface targeting and mediates internalization of oligomeric beta amyloid
por: Tsay, Huey-Jen
Publicado: (2013)

AQP4 Attenuated TRAF6/NFκB Activation in Acrylamide-Induced Neurotoxicity
por: Hung, Chia-Yu, et al.
Publicado: (2022)

The role of bioactive lipids in attenuating the neuroinflammatory cascade in traumatic brain injury
por: Poblete, Roy A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vbj6nqprjdtlfjvs0pjckfiuch